Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015, Article ID 424019, 8 pages
Review Article

TNF-Related Apoptosis Inducing Ligand in Ocular Cancers and Ocular Diabetic Complications

1Department of Biomedical and Specialist Surgical Sciences, University of Ferrara, 44121 Ferrara, Italy
2Institute for Maternal and Child Health-IRCCS “Burlo Garofolo”, 34137 Trieste, Italy
3Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, 44121 Ferrara, Italy
4Department of Life Sciences, University of Trieste, 34137 Trieste, Italy

Received 19 January 2015; Accepted 17 February 2015

Academic Editor: Maurizio Battaglia Parodi

Copyright © 2015 Paolo Perri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


TNF-related apoptosis inducing ligand (TRAIL) is an intensively studied cytokine, in particular for its anticancer activity. The discovery that conjunctival sac fluid contains extremely high levels of soluble TRAIL as compared to other body fluids suggested important implications in the context of the immunological surveillance of the eye, in particular of the anterior surface. In this review, we discuss the potential physiopathologic and therapeutic role of the TRAIL/TRAIL receptor system in a variety of ocular cancers. Moreover, since an increasing amount of data has indicated the important biological activities of the TRAIL/TRAIL receptor systems also in a completely different pathologic context such as diabetes mellitus, in the second part of this review we summarize the currently available data on the involvement of TRAIL in the ocular complications of diabetes mellitus as modulator of the inflammatory and angiogenic response in the eye.