Prediction of Metabolic Gene Biomarkers for Neurodegenerative Disease by an Integrated Network-Based Approach

Table 1

Predicted enzyme-coding genes with top 10 closest mean shortest paths to known disease genes.

Disease	Gene symbol	Protein annotation
	ALDOA	Fructose-bisphosphate aldolase A
	PFKM	ATP-dependent 6-phosphofructokinase, muscle type
	GOT2	Aspartate aminotransferase, mitochondrial
	ALDH2	Aldehyde dehydrogenase, mitochondrial
PD	HADHB	Trifunctional enzyme subunit beta, mitochondrial
	MTHFD1	C-1-Tetrahydrofolate synthase, cytoplasmic
	ALDH9A1	4-Trimethylaminobutyraldehyde dehydrogenase
	INPPL1	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
	ECHS1	Enoyl-CoA hydratase, mitochondrial
	OGDH	2-Oxoglutarate dehydrogenase, mitochondrial
	ALDOA	Fructose-bisphosphate aldolase A
	GPI	Glucose-6-phosphate isomerase
	PFKM	ATP-dependent 6-phosphofructokinase, muscle type
	IMPDH2	IMP (inosine 5′-monophosphate) dehydrogenase 2
HD	GLA	Alpha-galactosidase A
	SPTLC1	Serine palmitoyltransferase 1
	AK1	Adenylate kinase isoenzyme 1
	EHHADH	Peroxisomal bifunctional enzyme
	POLE3	DNA polymerase epsilon subunit 3
	DCK	Deoxycytidine kinase