The Impact of Microgravity and Hypergravity on Endothelial Cells

Table 3

Summary of the principal parameters influenced by simulated microgravity and hypergravity in different types of ECs.

	Microgravity					Hypergravity
	Endothelial cell line EA.hy926	Dermal HMEC	HUVEC	PAEC	BAEC	Endothelial cell line EA.hy926	HUVEC	CVEC	BAEC
Migration	↓	=	=/↑	↓	ND	ND	↑	ND	↑
Proliferation	ND	↓	↑	↓	↑	ND (=/↑)	=	ND	↑
Apoptosis	↑	=	=	↑	=	=/↓	=	=	=
NO synthesis	↑	↑	↑	ND	↑	ND	↑	ND	ND
Cytoskeletal rearrangements	+++	+++	+++	+++	+++	+++	++	+++	+++

Legend: ↑, increased; ↓, decreased; =, no change; ND, not determined; ++ and +++, highly and strongly upregulated.