The Genetic Deletion of 6q21 and PRDM1 and Clinical Implications in Extranodal NK/T Cell Lymphoma, Nasal Type

Figure 2

Two representative EN-NK/T-NT cases without deletion of 6q21 or PRDM1 gene. Dual-color FISH was performed with 6q21 probe or PRDM1 specific probe (labelled with 5-carboxyl-xrhodamine, red) and chromosome 6 centromere specific probe (labelled with 5-fluorescein, green), respectively. Case , (a), (b), and (c): one case without deletion of 6q21 (a, two green and two red) or PRDM1 gene (b, two green and two red) showed PRDM1 positive immunostaining (c). Case , (d), (e), and (f): another representative case without deletion of 6q21 (d, two green and two red) or PRDM1 gene (e, two green and two red) presented PRDM1 positive immunostaining (f). (a, b, d, and e at 1000x magnification; c and f at 400x magnification).