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BioMed Research International
Volume 2015 (2015), Article ID 435737, 12 pages
Review Article

Noninvasive Physiologic Assessment of Coronary Stenoses Using Cardiac CT

1Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China
2Discipline of Medical Imaging, Department of Imaging and Applied Physics, Curtin University, Perth, WA 6845, Australia

Received 21 June 2014; Revised 29 September 2014; Accepted 6 October 2014

Academic Editor: Michael Ralph Rees

Copyright © 2015 Lei Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Coronary CT angiography (CCTA) has become an important noninvasive imaging modality in the diagnosis of coronary artery disease (CAD). CCTA enables accurate evaluation of coronary artery stenosis. However, CCTA provides limited information on the physiological significance of stenotic lesions. A noninvasive “one-stop-shop” diagnostic test that can provide both anatomical significance and functional significance of stenotic lesions would be beneficial in the diagnosis and management of CAD. Recently, with the introduction of novel techniques, such as myocardial CT perfusion, CT-derived fractional flow reserve (), and transluminal attenuation gradient (TAG), CCTA has emerged as a noninvasive method for the assessment of both anatomy of coronary lesions and its physiological consequences during a single study. This review provides an overview of the current status of new CT techniques for the physiologic assessments of CAD.