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BioMed Research International
Volume 2015 (2015), Article ID 436314, 5 pages
http://dx.doi.org/10.1155/2015/436314
Review Article

Stem Cell-Based Therapies in Chagasic Cardiomyopathy

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rua Carlos Chagas Filho 373, 21949-900 Rio de Janeiro, RJ, Brazil

Received 24 March 2015; Accepted 27 May 2015

Academic Editor: Junjie Xing

Copyright © 2015 Antonio Carlos Campos de Carvalho and Adriana Bastos Carvalho. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Chagas disease is caused by Trypanosoma cruzi and can lead to a dilated cardiomyopathy decades after the prime infection by the parasite. As with other dilated cardiomyopathies, conventional pharmacologic therapies are not always effective and as heart failure progresses patients need heart transplantation. Therefore alternative therapies are highly desirable and cell-based therapies have been investigated in preclinical and clinical studies. In this paper we review the main findings of such studies and discuss future directions for stem cell-based therapies in chronic chagasic cardiomyopathy.