Experimental Protoporphyria: Effect of Bile Acids on Liver Damage Induced by Griseofulvin

Figure 2

Effect of bile acids on liver/body weight ratio and on enzymes marker of cholestasis. (a) Liver and body weight ratio; (b) GGT, mean control value: 38.97 ± 5.0 μU/mL (); (c) AP mean control value:  mU/mL (). Mice received standard diet containing Gris (0.5%, w/w), DHA (0.33% w/w), CHENO (0.01% w/w), DXA (0.33% w/w), URSO (0.20% w/w), or Gris plus one of the bile acids indicated before, during 14 days. Control group received only standard diet in oil (vehicle used for solubilising Gris). Data represent mean values ± S.D. of 6 mice. Results in Figure (b) and (c) are expressed as percentage of the corresponding control value taken as 100%. significance of differences between groups treated and the control group. and , significance of differences between the group treated with Gris plus bile acid with respect to the group receiving only bile acid. and , significance of differences between the group treated with Gris plus bile acid with respect to the group that received only Gris. Other experimental details are described in Section 2.

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