Experimental Protoporphyria: Effect of Bile Acids on Liver Damage Induced by Griseofulvin

Table 1

Effect of bile acids on PROTO IX levels in liver and feces.

Bile acid	PROTO IX levels
	Liver (ng/mg protein)		Feces (ng/mg feces)
	Without Gris	With Gris	Without Gris	With Gris
NBA	0.42 ± 0.04	20.25 ± 3.5	2.22 ± 0.04	10.25 ± 0.4
DHA	0.47 ± 0.07	2.88 ± 0.6	3.88 ± 0.06	32.12 ± 0.5
CHENO	0.44 ± 0.06	20.94 ± 2.1	6.58 ± 0.008	6.85 ± 0.06
DXA	0.43 ± 0.09	1.11 ± 0.2	2.53 ± 0.004	31.82 ± 0.3
URSO	0.51 ± 0.07	27.59 ± 3.5	02.07 ± 0.05	4.55 ± 0.0

NBA: no bile acid added.
Mice received standard diet containing Gris (0.5%, w/w), DHA (0.33% w/w), CHENO (0.01% w/w), DXA (0.33% w/w), URSO (0.20% w/w), or Gris plus one of the bile acids, over 14 days. Control group received only standard diet in oil (vehicle used for solubilising Gris). Data represent mean values ± S.D. of 6 mice. : significant difference between the groups treated with respect to the control group. significance of differences between the group treated with Gris plus bile acid with respect to the group that received only Gris. : significant difference between the group treated with Gris plus bile acid with respect to the group treated only with bile acid. Other experimental details are described in Section 2.