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BioMed Research International
Volume 2015, Article ID 450805, 5 pages
http://dx.doi.org/10.1155/2015/450805
Clinical Study

Analgesic Effects of Intra-Articular Bupivacaine/Intravenous Parecoxib Combination Therapy versus Intravenous Parecoxib Monotherapy in Patients Receiving Total Knee Arthroplasty: A Randomized, Double-Blind Trial

1Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
2College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
3Department of Nursing, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
4Clinical Informatics and Medical Statistics Research Center, Chang Gung University, Taoyuan 333, Taiwan
5Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Chiayi 613, Taiwan

Received 14 May 2015; Accepted 2 June 2015

Academic Editor: Sebastian Straube

Copyright © 2015 Shih-Jyun Shen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. The purpose of this double-blind, randomized study was to investigate whether the addition of intra-articular bupivacaine to intravenous parecoxib could improve pain relief in patients undergoing total knee arthroplasty. Methods. A total of 36 patients undergoing total knee arthroplasty were enrolled into our study. These patients were randomly allocated either to a placebo-controlled group or study group. Postoperative pain scores and analgesic consumption were evaluated. Results. Numeric rating scale (NRS) data of bupivacaine group in postoperative room were significantly lower than that of control group (control group versus bupivacaine group, 7.9 (6.7–9.1) (mean and 95% confidence interval) versus 4.5 (3.2–5.8) (mean and 95% confidence interval), ). NRS data of bupivacaine group in ward were also significantly lower than that of control group. A significantly lower dose of meperidine was used in the study group postoperatively during the first 24 hours (control group versus bupivacaine group, 3.08 ± 0.80 mg/Kg versus 2.34 ± 0.42 mg/Kg, ). Conclusion. Intra-articular bupivacaine in combination with intravenous parecoxib may improve pain relief and reduce the demand for rescue analgesics in patients undergoing total knee arthroplasty. The trial is registered with Australian New Zealand Clinical Trials Registry (ACTRN12615000463572).