Multiple Sclerosis in Older Adults: The Clinical Profile and Impact of Interferon Beta Treatment

Figure 1

Multivariable Cox regression analysis of potential factors associated with time to reach confirmed and sustained EDSS 6 from onset of MS symptoms in patients with relapsing-onset (a) and primary-progressive (b) MS.Out of 5373 patients with relapsing-onset MS, 874 patients did not contribute to the analysis (i.e., were excluded from the analyses). Those included 640 patients who had already reached the outcome by first clinic assessment (i.e., were left-censored), 185 patients with no EDSS score recorded, and 49 patients who were censored before the earliest event. ^†Reference level = absence of the specific onset symptom. ^‡Out of 612 patients with primary-progressive MS, 273 patients did not contribute to the analysis (including 234 patients who had already reached the outcome by first clinic assessment (i.e., left-censored), 33 patients with no EDSS score recorded, and 6 patients who were censored before the earliest event).

(a) Relapsing-onset MS patients

(b) Primary-progressive MS patients ()^‡