Probing the Surface of Human Carbonic Anhydrase for Clues towards the Design of Isoform Specific Inhibitors

Figure 3

CA inhibition mechanism. (a) Anions such as thiocyanate form trigonal-bipyramidal adducts (b) Anions such as Br⁻ form distorted tetrahedral adducts (c) sulfonamides as well as some anions form regular tetrahedral adducts.

(a)

(b)

(c)