Probing the Surface of Human Carbonic Anhydrase for Clues towards the Design of Isoform Specific Inhibitors

Figure 8

CA inhibitor: (a) several inhibitors binding in the conserved region (green) of CA II’s active site. These inhibitors are buried in the active site and are stabilized predominantly by hydrophobic residues (b). Several inhibitors occupying the “selective pocket” (yellow) of CA II. The tails of these inhibitors are extending out of the active site. (c) Coumarin binding on the perimeter of the active site. (d) Phenol binding in the proximity of the active site.

(a)

(b)

(c)

(d)