Probing the Surface of Human Carbonic Anhydrase for Clues towards the Design of Isoform Specific Inhibitors

Table 4

Hydrophobicity of CA active sites (CA II numbering).

Residues	Isozyme
	I^1	II^2	III^3	IV^4		VI^6	VII^7	IX^8	XII^9	XIII^10	XIV^11
I91	F	I	R	K	K	Q	K	L	T	R	A
V121	A	V	V	V	V	V	V	V	V	V	V
V135	A	V	L	Q	S	Q	A	L	S	A	A
V141	L	L	L	I	L	L	L	L	L	L	L
V143	V	V	V	V	V	V	V	V	V	V	V
L198	L	L	F	L	L	L	L	L	L	L	L
P202	P	P	T	P	P	P	P	P	P	P	P
L204	Y	L	E	D	A	T	S	A	N	L	Y
W209	W	W	W	W	W	W	W	W	W	W	W
Total hydrophobicity	14	26	8	4	11	7	11	23	9	15	16

2FOY; ²3KS3; ³3UYN; ⁴1ZNC; ⁵1DMX ^*murine; ⁶3FE4; ⁷3MDZ; ⁸3IAI; ⁹1JC2; ¹⁰3DAZ; ¹¹4LU3.