The Effect of Iloprost and N-Acetylcysteine on Skeletal Muscle Injury in an Acute Aortic Ischemia-Reperfusion Model: An Experimental Study

Table 3

Comparison of histopathological results.

Parameters	Groups	Median (25–75 perc.)	Statistical test ()	value
Loss of striation	Group 1	0 (0-0)	14.467	<0.05
	Group 2	1.5 (1-2)
	Group 3	0 (0-1)
	Group 4	1 (0-1)
Faint peripheral nuclei	Group 1	0 (0-0)	3.932	NS
	Group 2	0 (0-0)
	Group 3	0 (0-0)
	Group 4	0 (0-0)
Necrosis	Group 1	0 (0-0)	19.172	<0.05
	Group 2	1.5 (1-2)
	Group 3	0.5 (0-1)
	Group 4	1 (0-1)
Cellular swelling	Group 1	0 (0-0)	11.766	<0.05
	Group 2	1 (0-1)
	Group 3	0 (0-0)
	Group 4	0 (0-1)
Edema	Group 1	0.5 (0-1)	9.415	<0.05
	Group 2	2 (1–3)
	Group 3	1 (0–2)
	Group 4	1.5 (1-2)
Fibrosis	Group 1	0 (0-0)	17.759	<0.05
	Group 2	2 (1-2)
	Group 3	1 (0–2)
	Group 4	2 (1–3)
Leukocyte accumulation in capillaries	Group 1	0 (0-0)	13.064	<0.05
	Group 2	2 (2-2)
	Group 3	0.5 (0–2)
	Group 4	0 (0-1)
Congestion	Group 1	0 (0-0)	15.957	<0.05
	Group 2	2 (1-2)
	Group 3	2 (2-3)
	Group 4	1.5 (0–2)
Hemorrhage	Group 1	0 (0-0)	2.274	NS
	Group 2	0 (0-0)
	Group 3	0 (0-0)
	Group 4	0 (0-0)
PMNL infiltration	Group 1	0 (0-0)	21.263	<0.05
	Group 2	3 (3-3)
	Group 3	1.5 (1-2)
	Group 4	0 (0–2)
Monocyte-macrophage infiltration	Group 1	0 (0-1)	15.755	<0.05
	Group 2	2.5 (2-3)
	Group 3	1 (0–2)
	Group 4	0.5 (0–2)

NS: not significant.