Targeting Cellular Metabolism Chemosensitizes the Doxorubicin-Resistant Human Breast Adenocarcinoma Cells

Figure 1

Energy restriction induced by 2DG inhibited the proliferation of MCF-7/MDR cells. (a) The establishment of MCF-7/MDR cells. (b) 2DG depressed the proliferation of MCF-7/MDR cells in a dose-dependent manner. (c) 2DG depleted the level of intercellular ATP. (d) 2DG enhanced the cytotoxicity of DOX.

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