Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015, Article ID 453986, 8 pages
http://dx.doi.org/10.1155/2015/453986
Research Article

Targeting Cellular Metabolism Chemosensitizes the Doxorubicin-Resistant Human Breast Adenocarcinoma Cells

1Training Center of Medical Experiments, Basic Medical School, Fudan University, Shanghai 200032, China
2Department of Oncology, Shanghai Xuhui Central Hospital, Shanghai 200031, China
3Institute of Radiation Medicine, Fudan University, Shanghai 200032, China

Received 27 June 2015; Revised 25 September 2015; Accepted 29 September 2015

Academic Editor: Siyaram Pandey

Copyright © 2015 Shulan Ma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. Kroemer and J. Pouyssegur, “Tumor cell metabolism: cancer's Achilles' heel,” Cancer Cell, vol. 13, no. 6, pp. 472–482, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. S. S. Gambhir, “Molecular imaging of cancer with positron emission tomography,” Nature Reviews Cancer, vol. 2, no. 9, pp. 683–693, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. R. van Horssen, R. Buccione, M. Willemse, S. Cingir, B. Wieringa, and F. Attanasio, “Cancer cell metabolism regulates extracellular matrix degradation by invadopodia,” European Journal of Cell Biology, vol. 92, no. 3, pp. 113–121, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. U. E. Martinez-Outschoorn, Z. Lin, Y.-H. Ko et al., “Understanding the metabolic basis of drug resistance: therapeutic induction of the Warburg effect kills cancer cells,” Cell Cycle, vol. 10, no. 15, pp. 2521–2528, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. A. A. Kovalev, D. A. Tsvetaeva, and T. V. Grudinskaja, “Role of ABC-cassette transporters (MDR1, MRP1, BCRP) in the development of primary and acquired multiple drug resistance in patients with early and metastatic breast cancer,” Experimental Oncology, vol. 35, no. 4, pp. 287–290, 2013. View at Google Scholar · View at Scopus
  6. B. Shen, P.-J. He, and C.-L. Shao, “Norcantharidin induced DU145 cell apoptosis through ROS-mediated mitochondrial dysfunction and energy depletion,” PLoS ONE, vol. 8, no. 12, Article ID e84610, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. C.-H. Tang, W.-Y. Wu, S.-C. Tsai, T. Yoshinaga, and T.-H. Lee, “Elevated Na+/K+-ATPase responses and its potential role in triggering ion reabsorption in kidneys for homeostasis of marine euryhaline milkfish (Chanos chanos) when acclimated to hypotonic fresh water,” Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology, vol. 180, no. 6, pp. 813–824, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Fontaine, W. F. Elmquist, and D. W. Miller, “Use of rhodamine 123 to examine the functional activity of P-glycoprotein in primary cultured brain microvessel endothelial cell monolayers,” Life Sciences, vol. 59, no. 18, pp. 1521–1531, 1996. View at Publisher · View at Google Scholar · View at Scopus
  9. M. G. V. Heiden, L. C. Cantley, and C. B. Thompson, “Understanding the warburg effect: the metabolic requirements of cell proliferation,” Science, vol. 324, no. 5930, pp. 1029–1033, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Wolf, S. Agnihotri, J. Micallef et al., “Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme,” Journal of Experimental Medicine, vol. 208, no. 2, pp. 313–326, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. Z. Zhu, W. Jiang, J. N. McGinley, and H. J. Thompson, “2-deoxyglucose as an energy restriction mimetic agent: effects on mammary carcinogenesis and on mammary tumor cell growth in vitro,” Cancer Research, vol. 65, no. 15, pp. 7023–7030, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. B. Viollet, S. Horman, J. Leclerc et al., “AMPK inhibition in health and disease,” Critical Reviews in Biochemistry and Molecular Biology, vol. 45, no. 4, pp. 276–295, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. O. Legrand, G. Simonin, A. Beauchamp-Nicoud, R. Zittoun, and J.-P. Marie, “Simultaneous activity of MRP1 and Pgp is correlated with in vitro resistance to daunorubicin and with in vivo resistance in adult acute myeloid leukemia,” Blood, vol. 94, no. 3, pp. 1046–1056, 1999. View at Google Scholar · View at Scopus
  14. A. V. Kabanov, E. V. Batrakova, and V. Y. Alakhov, “An essential relationship between ATP depletion and chemosensitizing activity of Pluronic block copolymers,” Journal of Controlled Release, vol. 91, no. 1-2, pp. 75–83, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Daniel, C. Bell, C. Burton, S. Harguindey, S. J. Reshkin, and C. Rauch, “The role of proton dynamics in the development and maintenance of multidrug resistance in cancer,” Biochimica et Biophysica Acta, vol. 1832, no. 5, pp. 606–617, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. C. Howarth, P. Gleeson, and D. Attwell, “Updated energy budgets for neural computation in the neocortex and cerebellum,” Journal of Cerebral Blood Flow and Metabolism, vol. 32, no. 7, pp. 1222–1232, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. R. A. Deshpande, G. J. Williams, O. Limbo et al., “ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling,” The EMBO Journal, vol. 33, no. 5, pp. 482–500, 2014. View at Publisher · View at Google Scholar · View at Scopus