High Order Gene-Gene Interactions in Eight Single Nucleotide Polymorphisms of Renin-Angiotensin System Genes for Hypertension Association Study

Figure 2

Comparison of the performance of MDR and the unbalanced function based MDR with the example of 2-locus SNPs. (a and c) Frequencies of TP, TN, and misclassification error. (b and d) The numbers of high- and low-risk groups. (a and c) The left scale of vertical axis is the log₁₀ value for the total numbers of TP and TN. The right scale of vertical axis is the error rate. Blue line is the error rate based on (7), denoted by “Adjust Err”. The horizontal axis represents the 100 different models in 2-locus combinations, in which the models are sorted by error rate and selected by systematic sampling from all models. (b and d) The high/low lines indicate the distribution difference between the numbers of high- and low-risk groups.

(a)

(b)

(c)

(d)