High Order Gene-Gene Interactions in Eight Single Nucleotide Polymorphisms of Renin-Angiotensin System Genes for Hypertension Association Study
Table 3
Two-locus SNP-SNP interactions among eight SNPs assessed by unbalanced function based on MD.
2 loci
OR values
P values
Error rates
AGT T174M + ACE I/D
1.982 (1.243–3.160)
0.004
0.423
AGT M235T + AGT G-6A
7.360 (1.734–31.236)
0.007
0.452
AGT M235T + ACE I/D
1.803 (1.161–2.799)
0.009
0.429
AGT G-6A + AGT A-20C
3.696 (1.094–12.492)
0.035
0.468
AGT G-6A + AGT G-217A
1.886 (1.067–3.331)
0.029
0.451
AGT G-6A + ACE I/D
1.854 (1.187–2.895)
0.007
0.426
AGT A-20C + ACE I/D
2.075 (1.244–3.461)
0.005
0.428
AGT G-217A + ACE I/D
2.054 (1.310–3.221)
0.003
0.419
AGT G-152A + ACE I/D
2.033 (1.227–3.369)
0.006
0.428
ACE I/D + AT1R A1166C
1.801 (1.104–2.938)
0.018
0.438
All 2-locus SNP-SNP interactions are identified by the unbalanced function based on MDR method with significant testing accuracy but not best CVC. Bold type represents the best model in 2-locus SNP-SNP interaction models.
