BioMed Research International / 2015 / Article / Tab 3

Research Article

High Order Gene-Gene Interactions in Eight Single Nucleotide Polymorphisms of Renin-Angiotensin System Genes for Hypertension Association Study

Table 3

Two-locus SNP-SNP interactions among eight SNPs assessed by unbalanced function based on MD.

2 lociOR valuesP valuesError rates

AGT T174M + ACE I/D1.982 (1.243–3.160)0.0040.423
AGT M235T + AGT G-6A7.360 (1.734–31.236)0.0070.452
AGT M235T + ACE I/D1.803 (1.161–2.799)0.0090.429
AGT G-6A + AGT A-20C3.696 (1.094–12.492)0.0350.468
AGT G-6A + AGT G-217A1.886 (1.067–3.331)0.0290.451
AGT G-6A + ACE I/D1.854 (1.187–2.895)0.0070.426
AGT A-20C + ACE I/D2.075 (1.244–3.461)0.0050.428
AGT G-217A + ACE I/D2.054 (1.310–3.221)0.0030.419
AGT G-152A + ACE I/D2.033 (1.227–3.369)0.0060.428
ACE I/D + AT1R A1166C1.801 (1.104–2.938)0.0180.438

All 2-locus SNP-SNP interactions are identified by the unbalanced function based on MDR method with significant testing accuracy but not best CVC. Bold type represents the best model in 2-locus SNP-SNP interaction models.

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