High Order Gene-Gene Interactions in Eight Single Nucleotide Polymorphisms of Renin-Angiotensin System Genes for Hypertension Association Study

Table 4

Multiloci analysis of hypertension using unbalanced function based MDR.

Loci number (SNP combination)	Consistency	Error^a (%)	OR values (95% CI)	Power	Boot-OR^b (95% CI)	P^c values
2 loci (G-217A; ACE I/D)	4/10	41.9	2.054; (1.31–3.22)	0.901	1.972; (1.26–3.09)	0.003
3 loci (G-6A; G-217A; ACE I/D)	4/10	40.3	2.372; (1.51–3.73)	0.986	2.232; (1.42–3.51)
4 loci (T174M; G-6A; G-217A; ACE I/D)	4/10	38.7	2.810; (1.75–4.52)	0.999	2.759; (1.71–4.44)
5 loci (T174M; G-6A; G-152A; G-217A; ACE I/D)	4/10	37.0	3.241; (1.99–5.28)	0.999	3.240; (1.99–5.29)
6 loci (T174M; G-6A; A-20C; G-152A; G-217A; ACE I/D)	6/10	35.3	3.863; (2.36–6.33)	0.999	3.785; (2.31–6.21)
7 loci (T174M; G-6A; A-20C; G-152A; G-217A; ACE I/D; AT1R)	6/10	33.8	4.510; (2.77–7.34)	0.999	4.050; (2.49–6.58)
8 loci (T174M; M235T; G-6A; A-20C; G-152A; G-217A; ACE I/D; AT1R)	10/10	32.6	4.628; (2.84–7.54)	0.999	4.483; (2.76–7.29)

 ^aIt was determined empirically by permutation testing. ^bBootstrapping 1000 samples. ^cChi-square test.