Activation of Endocannabinoid System Is Associated with Persistent Inflammation in Human Aortic Aneurysm

Figure 2

Infiltration of aortic wall with inflammatory cells. Representative image of newly recruited leukocytes stained with MAC-387 antibody (a) in aorta from patients with coronary artery disease (CAD) and (b) from aneurysm of the ascending aorta (AAA). Arrows indicate the stained leukocytes and the dotted line delineates the adventitia (a) from the media (m). (c) Quantitative analysis of newly recruited leukocytes showed comparable cell density between the groups with significantly higher density in adventitia than in the media. Representative image of mononuclear cells stained using CD11b antibody in (d) aorta from CAD and (e) from AAA patient. (f) Quantitative analysis of mononuclear cells showed significantly higher cell density in adventitia of AAA samples than in CAD samples or respective media of the aortic wall. Scale bar in (a), (b), (d), and (e): 200 μm. in the AAA group and in the CAD histology group. Bracket indicates between the groups; indicates versus media.

(a)

(b)

(c)

(d)

(e)

(f)