BioMed Research International / 2015 / Article / Tab 1 / Research Article
Robust Association Tests for the Replication of Genome-Wide Association Studies Table 1 Type I error rates of three approaches—replication-based (REP) test, Fisher’s combination (
), and linear combination of test (
)—based on the CATT with an additive model (
),
, MAX3, MIN2, GMS, and GME. The disease prevalence
,
markers,
cases, and
controls are considered based on 20,000 simulations.
MAF MAX3 MIN2 GMS GME 0.3 0.5 0.05 REP 0.00530 0.00455 0.00505 0.00485 0.0050 0.00490 0.00500 0.00535 0.00495 0.00510 0.00515 0.00460 0.00535 0.00525 0.00485 0.00510 0.0050 0.00485 0.1 REP 0.00510 0.00560 0.00565 0.00485 0.00525 0.00545 0.00565 0.00535 0.00565 0.00545 0.00565 0.00540 0.00520 0.00565 0.00525 0.00520 0.00530 0.00525 0.3 0.6 0.05 REP 0.00510 0.00485 0.00480 0.00515 0.00480 0.00500 0.00445 0.00455 0.00450 0.00455 0.00450 0.00460 LC 0.00500 0.00515 0.00495 0.00520 0.00475 0.00480 0.1 REP 0.00500 0.00485 0.00485 0.00535 0.00530 0.00505 0.00465 0.00490 0.00485 0.00500 0.00455 0.00460 0.00480 0.00470 0.00515 0.00490 0.00485 0.00475 0.4 0.5 0.05 REP 0.00590 0.00505 0.00530 0.00565 0.00505 0.00510 0.00575 0.00430 0.00460 0.00535 0.00460 0.00500 0.00600 0.00445 0.00500 0.00540 0.00490 0.00490 0.1 REP 0.00525 0.00470 0.00535 0.00450 0.00480 0.00515 0.00515 0.00510 0.00495 0.00475 0.00540 0.00500 0.00530 0.00500 0.00485 0.00475 0.00495 0.00510 0.4 0.6 0.05 REP 0.00475 0.00585 0.00480 0.00500 0.00515 0.00495 0.00460 0.00470 0.00420 0.00490 0.00455 0.00440 0.00525 0.00550 0.00520 0.00580 0.00510 0.00510 0.1 REP 0.00550 0.00490 0.00515 0.00535 0.00555 0.00540 0.00520 0.00370 0.00495 0.00450 0.00515 0.00510 0.00565 0.00485 0.00570 0.00530 0.00610 0.00580
