Chronic Ingestion of High Dosed Phikud Navakot Extraction Induces Mesangiolysis in Rats with Alteration of AQP1 and Hsp60 Expressions

Table 1

Sprague Dawley mean hematological value in chronic oral toxicity test.

Group	WBC; (10^3 µL)	RBC; (10^6 µL)	HCT; (g/dL)	MCV; (%)	MCH; (fl)	MCHC; (pg)	PLT; (g/dL)	RDW; (10^5 µL)	PDW; (%)	MPV; (fl)	PCT; (fl)	Differential count (%)
												(%)	Nuet	Lymph	Eosi	Mono
Male
Control
Mean	4.32	8.01	15.29	43.46	54.32	19.12	35.19	910.93	18.01	17.71	7.65	0.70	25.14	65.95	1.55	0.00
SD	2.12	0.36	0.61	1.38	1.10	0.72	1.27	91.15	0.89	0.56	0.33	0.07	6.55	7.96	0.72	0.00
10 mg/kg
Mean	5.94	8.02	15.45	43.88	54.75	19.29	35.23	988.69	17.69	17.58	7.60	0.75	23.45	66.48	2.11	0.00
SD	2.63	0.31	0.53	1.58	0.95	0.86	1.13	69.75	0.58	0.37	0.35	0.06	4.68	7.21	0.94	0.00
100 mg/kg
Mean	4.94	8.06	15.46	43.75	54.34	19.20	35.33	983.17	18.13	17.54	7.62	0.75	21.41	71.81	1.84	0.00
SD	1.64	0.38	0.72	1.68	1.09	0.83	1.21	87.48	0.79	0.44	0.35	0.06	10.20	10.80	0.94	0.00
1,000 mg/kg
Mean	6.57	8.15	15.56	43.64	53.55	19.08	35.65	984.64	17.71	17.74	7.73	0.76	18.59	73.57	1.89	0.00
SD	1.32	0.28	0.59	0.92	1.06	0.64	1.05	65.33	0.84	0.48	0.49	0.06	5.24	7.91	0.92	0.00
Female
Control
Mean	4.60	8.04	16.03	45.05	56.06	19.98	35.62	758.50	16.39	18.17	8.15	0.61	18.18	74.09	2.08	0.00
SD	1.63	0.32	0.55	1.57	0.74	0.61	0.99	167.94	0.70	1.18	1.13	0.15	11.32	14.09	1.26	0.00
10 mg/kg
Mean	4.05	7.79	15.73	44.21	56.74	20.20	35.61	754.86	16.28	17.90	7.93	0.60	19.24	67.69	2.62	0.00
SD	1.70	0.39	0.75	1.80	0.68	0.82	1.26	65.17	0.69	0.44	0.47	0.06	7.72	7.75	1.52	0.00
100 mg/kg
Mean	4.19	7.84	15.61	44.32	56.56	19.94	35.23	824.18	16.09	17.65	7.93	0.65	18.42	73.60	2.46	0.00
SD	2.11	0.26	0.67	1.30	0.79	0.53	0.85	59.44	0.96	0.48	0.28	0.05	6.92	10.55	1.91	0.00
1,000 mg/kg
Mean	4.12	7.66	15.24	43.27	56.51	19.91	35.21	728.67	16.04	17.33	7.72	0.56	17.90	74.17	2.46	0.00
SD	0.95	0.35	0.72	1.74	1.23	0.84	0.87	72.59	0.76	0.60	0.35	0.05	9.72	11.57	1.96	0.00

WBC: white blood cell, RBC: red blood cell, HCT: hematocrit, MCV: mean corpuscular volume, MCH: mean corpuscular hemoglobin, MCHC: mean corpuscular hemoglobin concentration, PLT: platelet, RDW: red cell distribution width, PDW: platelet distribution width, MPV: mean platelet volume, PCT: plateletcrit, Neut: neutrophil, Lymph: lymphocyte, Eosi: eosinophil, Mono: monocyte.