Chronic Ingestion of High Dosed Phikud Navakot Extraction Induces Mesangiolysis in Rats with Alteration of AQP1 and Hsp60 Expressions
Table 3
Prevalence of histopathological changes in the liver, heart, lung, spleen, and kidney of both sexes among 10, 100, and 1,000 mg/kg/day dosages and control group.
Histopathological changes/parameter
Prevalence (%) or mean score
value
Control
PN (mg/kg/day)
10
100
1,000
Liver
Focal lymphocyte aggregation (mild)
30 (6/20)
25 (5/20)
21 (4/19)
12 (2/17)
0.600
Bile duct dilatation (mild)
10 (2/20)
5 (1/20)
5 (1/19)
0 (0/17)
0.605
Microvesicular steatosis (mild)
10 (2/20)
15 (3/20)
0 (0/19)
6 (1/17)
0.357
Macrovesicular steatosis (mild)
15 (3/20)
20 (4/20)
11 (2/19)
6 (1/17)
0.619
Bile duct hyperplasia (mild)
0 (0/20)
5 (1/20)
16 (3/19)
18 (3/17)
0.181
Hepatic karyorrhexis (mild)
85 (17/20)
90 (18/20)
95 (18/19)
94 (16/17)
0.707
Heart
Focal endocarditis (mild)
65 (13/20)
55 (11/20)
47 (9/19)
35 (6/17)
0.324
Focal coagulative necrosis (mild)
55 (11/20)
65 (13/20)
53 (10/19)
47 (8/17)
0.733
Lung
Peribronchial cuffing (moderate)
100 (20/20)
95 (19/20)
100 (19/19)
94 (16/17)
0.533
Perivascular edema (moderate)
75 (15/20)
70 (14/20)
89 (17/19)
88 (15/17)
0.177
Perivascular cuffing (moderate)
100 (20/20)
100 (20/20)
89 (17/19)
100 (17/17)
0.104
Alveolar septal thickening (moderate)
100 (20/20)
100 (20/20)
100 (19/19)
100 (17/17)
—
Alveologenic edema (moderate)
50 (10/20)
65 (13/20)
74 (14/19)
76 (13/17)
0.307
Histiocytosis (mild)
40 (8/20)
35 (7/20)
26 (5/19)
24 (4/17)
0.678
Tunica medial hyperplasia (moderate)
80 (16/20)
90 (18/20)
89 (17/19)
88 (15/17)
0.768
Spleen
Normal finding
Kidney
Renal pelvis calcification (moderate)
50 (10/20)
0 (0/20)
0 (0/19)
0 (0/17)
0.000
Tubular/interstitial calcification (mild)
100 (20/20)
85 (17/20)
84 (16/19)
82 (14/17)
0.768
Transitional cell hyperplasia (moderate)
35 (7/20)
5 (1/20)
0 (0/19)
0 (0/17)
0.002
CPN (early stage)
50 (10/20)
45 (9/20)
42 (8/19)
41 (7/17)
0.947
Pigmented tubules (mild)
75 (15/20)
60 (12/20)
68 (13/19)
65 (11/17)
0.782
Interstitial nephritis (mild)
55 (11/20)
65 (13/20)
53 (10/19)
53 (9/17)
0.847
Mesangiolysis: Lt kidney
10.37 ± 2.49
10.68 ± 7.98
12.27 ± 4.26
55.44 ± 22.2
0.000
: mean score
1.51 ± 0.39
1.31 ± 0.25
1.37 ± 0.24
1.50 ± 0.08
0.388
Mesangiolysis: Rt kidney
10.63 ± 2.87
7.05 ± 4.32
17.05 ± 3.05
44.58 ± 10.3
0.000
: mean score
1.42 ± 0.31
1.27 ± 0.19
1.33 ± 0.23
1.53 ± 0.22
0.211
CPN: chronic progressive nephropathy, Lt: left, and Rt: right.
