miRNA Profiles of Tubular Cells: Diagnosis of Kidney Injury

Figure 1

Heat map of microRNA (miRNA) expression in human tissues. (a) The expression profiles of 377 miRNAs in human tissues were examined with miRNA array analysis. Cluster analysis was performed with miR-122, miR-145, miR192, miR-194, miR-216a, the miR-200 family members, miR-217, and miR-449a. miR-200a, miR-200b, and miR-200c were highly expressed in the kidney, salivary gland, prostate, and colon. In addition, miR-200b and miR-200c were expressed in the lung, pancreas, and trachea. The cluster analysis discriminated between tubular tissues and tissues without a tubular structure (brain, heart, and skeletal muscle). Moreover, the lung and trachea were classified into the same branch. (b) The expression profiles of the 377 miRNAs in the human proximal tubule and mesangial cells were compared. Members of the miR-200 family were highly expressed in the proximal tubule.

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