miRNA Profiles of Tubular Cells: Diagnosis of Kidney Injury

Figure 2

Heat map of miRNA expression in rat tissues. (a) The expression profiles of 641 miRNAs in rat tissues were examined with miRNA array analysis. miR-200a, miR-200b, and miR-200c were highly expressed in the kidney, pancreas, salivary gland, prostate, lacrimal gland, lung, bile duct, and small intestine. Moreover, miR-122, miR-145, miR192, miR-194, miR-216a, the miR-200 family members, miR-217, and miR-449a exhibited a characteristic expression pattern in each tissue. (b) Small tissues consisting of epithelial cells were collected by laser-capture microdissection, and the miRNA expression profiles were examined. miR-200a, miR-200b, and miR-200c were highly expressed in these tissues. When the proximal tubule and glomerulus were compared, the expression of miR-200a, miR-200b, and miR-200c was higher in the proximal tubule than in the glomerulus.

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