Changes in B-Cell Counts and Percentages during Primary HIV Infection Associated with Disease Progression in HIV-Infected Men Who Have Sex with Men: A Preliminary Study
Table 1
Difference between HIV-infected and HIV-negative individuals.
Characteristics
HIV
HIV-negative
value
Gender male/female, number (%)
120 (100%)/0 (0%)
24 (100%)/0 (0%)
NS
Age at first visit, year, median (IQR)
29 (17–64)
32 (23–45)
NS
Ethnicity, Han/no Han, number (%)
112 (93.3%)/8 (6.7%)
24 (100%)/0 (0%)
NS
HIV subtype, number (%)
CRF01_AE
95 (79.2%)
—
Other
20 (16.7%)
—
Unknown
5 (4.1%)
—
Fiebig stages, number (%)
I
0 (0.0%)
—
II
19 (15.8%)
—
III
0 (0.0%)
—
IV
39 (32.5%)
—
V
21 (17.5%)
—
VI
41 (34.2%)
—
Baseline HIV viral load, median log10 copies/mL (IQR)
4.71 (2.02–7.00)
—
Baseline B-cell counts, cells/μL, median (IQR)
123 (30–448)
257 (126–616)
<0.001
Baseline B-cell percentages, %, median (IQR)
6 (1–26)
10 (6–20)
<0.001
Baseline CD4+ T-cell counts, cells/μL, median (IQR)
401 (87–1101)
748 (230–1682)
<0.001
Baseline CD8+ T-cell counts, cells/μL, median (IQR)
1176 (407–23449)
622 (159–1280)
<0.001
All HIV-infected subjects were anti-HIV treatment naive at study entry. HIV-infected and healthy HIV negative individuals were compared using the chi-square test for categorical variables, independent -test for normally distributed continuous variables, and the Mann–Whitney test for non-normally distributed continuous variables. HIV, HIV-infected individuals. HIV negative, healthy HIV negative individuals. NS, not significant, . Fiebig stages was based on a combination of the estimated time post-infection at sampling and ancillary HIV PCR, Western blot and/or ELISA results.
