Isotypes of Epstein-Barr Virus Antibodies in Rheumatoid Arthritis: Association with Rheumatoid Factors and Citrulline-Dependent Antibodies

Figure 1

Scattergrams showing individual levels of EAD IgG/IgM/IgA in plasma from RA patients, SLE patients, and HCs and individual levels of EAD IgG/IgM/IgA from RA patients divided into CCP IgG positives and negatives and divided into IgA RF and IgM RF positives and negatives. (a) EAD IgM/IgG/IgA levels. RA patients (), SLE patients (), and HCs (). (b) EAD IgM/IgG/IgA levels sorted into CCP IgG positives () and CCP IgG negatives (). RA patients total (). (c) EAD IgA levels sorted in IgA RF states, IgA RF positives () and IgA RF negatives (). EAD IgG levels sorted in RF states, RF positives () and RF negatives (). EAD IgM levels sorted in IgM RF states, IgM RF positives () and IgM RF negatives (). RA patients total (). Groups were compared using the Mann-Whitney test. Data are presented as mean ± SEM. Concentrations of antibodies are presented in arbitrary units. Statistical significant differences are indicated with , , , or for values less than 0.05, 0.01, 0.001, or 0.0001, respectively.

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