Review Article

Anesthesia Related Toxic Effects on In Vitro Fertilization Outcome: Burden of Proof

Table 1

Details of trials comparing different anesthetic techniques for in vitro fertilization.

First author/yearTechnique versus techniqueGroup sizePregnancy ratesFertilization rateCleavageOocytes (number and quality)

Aghaamoo et al. 2014 [2]GA versus spinal analgesia164 total
Spinal group ()
GA group
()
Spinal anesthesia is significantly related to increased chance of chemical pregnancy ()

Azmude et al. 2013 [1]GA versus spinal anesthesia200 total
GA group ()
Spinal group ()
Spinal anesthesia increased significantly the chance of IVF success ()

Milanini et al. 2008 [9]Local anesthesia versus remifentanil548 total
Group I ()
Group II ()
NS

Cerne et al. 2006 [4]Preovarian block (POB) versus paracervical block (PCB)183 total
POB group ()
PCB group ()
NSNSNS

Wilhelm et al. 2002 [6]Monitored anesthesia care (MAC) with remifentanil versus GA251 total
GA group ()
MAC group ()
MAC had a greater pregnancy rate
()
NSNSNS

Hammadeh et al. 1999 [8]GA versus sedation202 total
Sedation group ()
GA group ()
NSNSNSThe number of collected oocytes was significantly higher with general anesthesia ()

Ng et al. 1999 [3]Paracervical block with
1.5% lignocaine (group A) versus
normal saline (group B) versus
no local injection (group C)
135 total
Group A ()
Group B ()
Group C ()
NSNS

Christiaens et al. 1998 [7]Propofol versus
paracervical local anaesthetic block (PCB)
202 total
Propofol group ()
PCB group ()
NSNSNS

Botta et al. 1995 [5]Epidural anesthesia (group A) versus
Sedation (group B)
148 total
Group A ()
Group B ()
NSNSNS

NS: no significant difference, —: not under investigation.