SLC4A11 and the Pathophysiology of Congenital Hereditary Endothelial Dystrophy

Figure 3

Suggested molecular actions of the SLC4A11 protein. A: Electrogenic sodium/borate cotransporter [17]. B: conductive sodium permeation pathway [17]. C: conductive proton influx permeation pathway, which is thermodynamically equivalent to a hydroxyl efflux pathway [17, 18]. D: coupled electrogenic Na/H exchange, which is equivalent to electrogenic Na-OH cotransport () [19, 20]. E: permeation pathway [20]. F: H₂O permeation pathway [21].