Localized and Sustained Delivery of Erythropoietin from PLGA Microspheres Promotes Functional Recovery and Nerve Regeneration in Peripheral Nerve Injury

Figure 1

Characterization of EPO-PLGA microspheres. (a) EPO-PLGA microspheres analyzed by SEM. (b) Cell toxicity analysis of EPO-PLGA microspheres in vitro. Relative cell growth rates (left) and cell viabilities (right) were compared. (c) In vitro release profile of EPO from EPO-PLGA microspheres. Representative dot plot from triplicate experiments was shown. (d) Upper panel, western blotting analysis of EPO level from group PLGA/EPO and group EPO with GAPDH as a control. Lower panel, the relative in vivo concentration of EPO to the GAPDH control measured on different days after the injection was plotted and compared. Error bars stand for the S.D. from triplicate experiments (; ).

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