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BioMed Research International
Volume 2015, Article ID 478103, 7 pages
http://dx.doi.org/10.1155/2015/478103
Research Article

Localized and Sustained Delivery of Erythropoietin from PLGA Microspheres Promotes Functional Recovery and Nerve Regeneration in Peripheral Nerve Injury

1Department of Orthopedics, General Hospital of Chinese PLA, Beijing 100853, China
2Medical Department, Affiliated Hospital of Chinese PLA General Hospital, Beijing 100048, China

Received 6 December 2014; Accepted 9 February 2015

Academic Editor: Ali I. Abdalla

Copyright © 2015 Wei Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Z.-S. Yin, H. Zhang, and W. Gao, “Erythropoietin promotes functional recovery and enhances nerve regeneration after peripheral nerve injury in rats,” The American Journal of Neuroradiology, vol. 31, no. 3, pp. 509–515, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. G. Inoue, A. Gaultier, X. Li et al., “Erythropoietin promotes Schwann cell migration and assembly of the provisional extracellular matrix by recruiting β1 integrin to the cell surface,” Glia, vol. 58, no. 4, pp. 399–409, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. M. G. Lykissas, E. Sakellariou, M. D. Vekris et al., “Axonal regeneration stimulated by erythropoietin: an experimental study in rats,” Journal of Neuroscience Methods, vol. 164, no. 1, pp. 107–115, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. C. E. King, J. Rodger, C. Bartlett, T. Esmaili, S. A. Dunlop, and L. D. Beazley, “Erythropoietin is both neuroprotective and neuroregenerative following optic nerve transection,” Experimental Neurology, vol. 205, no. 1, pp. 48–55, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. J. M. Urra, M. De La Torre, R. Alcazar, and R. Peces, “Rapid method for detection of anti-recombinant human erythropoietin antibodies as a new form of erythropoietin resistance,” Clinical Chemistry, vol. 43, no. 5, pp. 848–849, 1997. View at Google Scholar · View at Scopus
  6. Y. Geng, W. Yuan, F. Wu, J. Chen, M. He, and T. Jin, “Formulating erythropoietin-loaded sustained-release PLGA microspheres without protein aggregation,” Journal of Controlled Release, vol. 130, no. 3, pp. 259–265, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. X. Rong, S. Yang, H. Miao et al., “Effects of erythropoietin-dextran microparticle-based PLGA/PLA microspheres on RGCS,” Investigative Ophthalmology and Visual Science, vol. 53, no. 10, pp. 6025–6034, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. N. Nafissi-Varcheh, V. Luginbuehl, R. Aboofazeli, and H. P. Merkle, “Preparing poly (lactic-co-glycolic acid) (PLGA) microspheres containing lysozyme-zinc precipitate using a modified double emulsion method,” Iranian Journal of Pharmaceutical Research, vol. 10, no. 2, pp. 203–209, 2011. View at Google Scholar · View at Scopus
  9. E. J. Lee, L. Xu, G.-H. Kim et al., “Regeneration of peripheral nerves by transplanted sphere of human mesenchymal stem cells derived from embryonic stem cells,” Biomaterials, vol. 33, no. 29, pp. 7039–7046, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. J. L. Cleland and A. J. S. Jones, “Stable formulations of recombinant human growth hormone and interferon-γ for microencapsulation in biodegradable microspheres,” Pharmaceutical Research, vol. 13, no. 10, pp. 1464–1475, 1996. View at Publisher · View at Google Scholar · View at Scopus
  11. M. L. Brines, P. Ghezzi, S. Keenan et al., “Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 19, pp. 10526–10531, 2000. View at Publisher · View at Google Scholar · View at Scopus
  12. R. Bianchi, B. Buyukakilli, M. Brines et al., “Erythropoietin both protects from and reverses experimental diabetic neuropathy,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 3, pp. 823–828, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. W. M. Campana and R. R. Myers, “Erythropoietin and erythropoietin receptors in the peripheral nervous system: changes after nerve injury,” The FASEB Journal, vol. 15, no. 10, pp. 1804–1806, 2001. View at Google Scholar · View at Scopus
  14. W. M. Campana and R. R. Myers, “Exogenous erythropoietin protects against dorsal root ganglion apoptosis and pain following peripheral nerve injury,” European Journal of Neuroscience, vol. 18, no. 6, pp. 1497–1506, 2003. View at Publisher · View at Google Scholar · View at Scopus