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BioMed Research International
Volume 2015, Article ID 481279, 11 pages
http://dx.doi.org/10.1155/2015/481279
Review Article

Theranostic Imaging of Yttrium-90

1Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA
2Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA

Received 1 January 2015; Accepted 22 April 2015

Academic Editor: Takahito Nakajima

Copyright © 2015 Chadwick L. Wright et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Xie, S. Lee, and X. Chen, “Nanoparticle-based theranostic agents,” Advanced Drug Delivery Reviews, vol. 62, no. 11, pp. 1064–1079, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. D. Minarik, K. Sjögreen Gleisner, and M. Ljungberg, “Evaluation of quantitative 90Y SPECT based on experimental phantom studies,” Physics in Medicine and Biology, vol. 53, no. 20, pp. 5689–5703, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. J. E. Dancey, F. A. Shepherd, K. Paul et al., “Treatment of nonresectable hepatocellular carcinoma with intrahepatic 90Y-microspheres,” Journal of Nuclear Medicine, vol. 41, no. 10, pp. 1673–1681, 2000. View at Google Scholar · View at Scopus
  4. K. Kossert and H. Schrader, “Activity standardization by liquid scintillation counting and half-life measurements of 90Y,” Applied Radiation and Isotopes, vol. 60, no. 5, pp. 741–749, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. V. Kyle, B. L. Hazleman, and E. P. Wraight, “Yttrium-90 therapy and 99MTc pertechnetate knee uptake measurements in the management of rheumatoid arthritis,” Annals of the Rheumatic Diseases, vol. 42, no. 2, pp. 132–137, 1983. View at Publisher · View at Google Scholar · View at Scopus
  6. T. Smith, J. C. W. Crawley, D. J. Shawe, and J. M. Gumpel, “SPECT using Bremsstrahlung to quantify 90Y uptake in Baker's cysts: its application in radiation synovectomy of the knee,” European Journal of Nuclear Medicine, vol. 14, no. 9-10, pp. 498–503, 1988. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Otte, E. Jermann, M. Behe et al., “DOTATOC: a powerful new tool for receptor-mediated radionuclide therapy,” European Journal of Nuclear Medicine, vol. 24, no. 7, pp. 792–795, 1997. View at Publisher · View at Google Scholar · View at Scopus
  8. M. De Jong, R. Valkema, F. Jamar et al., “Somatostatin receptor-targeted radionuclide therapy of tumors: preclinical and clinical findings,” Seminars in Nuclear Medicine, vol. 32, no. 2, pp. 133–140, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. S. J. Knox, M. L. Goris, K. Trisler et al., “Yttrium-90-labeled anti-CD20 monoclonal antibody therapy of recurrent B-cell lymphoma,” Clinical Cancer Research, vol. 2, no. 3, pp. 457–470, 1996. View at Google Scholar · View at Scopus
  10. P. K. Leichner, G. Akabani, D. Colcher et al., “Patient-specific dosimetry of indium-111- and yttrium-90-labeled monoclonal antibody CC49,” Journal of Nuclear Medicine, vol. 38, no. 4, pp. 512–516, 1997. View at Google Scholar · View at Scopus
  11. E. D. Grady, “Internal radiation therapy of hepatic cancer,” Diseases of the Colon and Rectum, vol. 22, no. 6, pp. 371–375, 1979. View at Publisher · View at Google Scholar · View at Scopus
  12. J. C. Andrews, S. C. Walker, R. J. Ackermann et al., “Hepatic radioembolization with yttrium-90 containing glass microspheres: Preliminary results and clinical follow-up,” Journal of Nuclear Medicine, vol. 35, no. 10, pp. 1637–1646, 1994. View at Google Scholar · View at Scopus
  13. W.-Y. Lau, W.-T. Leung, S. Ho et al., “Treatment of inoperable hepatocellular carcinoma with intrahepatic arterial yttrium-90 microspheres: a phase I and II study,” British Journal of Cancer, vol. 70, no. 5, pp. 994–999, 1994. View at Publisher · View at Google Scholar · View at Scopus
  14. Y.-H. Kao, J. D. Steinberg, Y.-S. Tay et al., “Post-radioembolization yttrium-90 PET/CT—part 1: diagnostic reporting,” EJNMMI Research, vol. 3, no. 1, article 56, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. D. Ersahin, I. Doddamane, and D. Cheng, “Targeted radionuclide therapy,” Cancers, vol. 3, no. 4, pp. 3838–3855, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. P. M. Anderson, G. A. Wiseman, A. Dispenzieri et al., “High-dose samarium-153 ethylene diamine tetramethylene phosphonate: low toxicity of skeletal irradiation in patients with osteosarcoma and bone metastases,” Journal of Clinical Oncology, vol. 20, no. 1, pp. 189–196, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. D. J. Hnatowich, F. Virzi, and P. W. Doherty, “DTPA-coupled antibodies labeled with Yttrium-90,” Journal of Nuclear Medicine, vol. 26, no. 5, pp. 503–509, 1985. View at Google Scholar · View at Scopus
  18. W. Y. Lau, T. W. T. Leung, S. Ho et al., “Diagnostic pharmaco-scintigraphy with hepatic intra arterial technetium-99m macroaggregated albumin in the determination of tumour to non-tumour uptake ratio in hepatocellular carcinoma,” The British Journal of Radiology, vol. 67, no. 794, pp. 136–139, 1994. View at Publisher · View at Google Scholar · View at Scopus
  19. W.-T. Leung, W.-Y. Lau, S. K. W. Ho et al., “Measuring lung shunting in hepatocellular carcinoma with intrahepatic- arterial technetium-99m macroaggregated albumin,” Journal of Nuclear Medicine, vol. 35, no. 1, pp. 70–73, 1994. View at Google Scholar · View at Scopus
  20. Y. H. Kao, E. H. Tan, T. K. B. Teo, C. E. Ng, and S. W. Goh, “Imaging discordance between hepatic angiography versus Tc-99m-MAA SPECT/CT: a case series, technical discussion and clinical implications,” Annals of Nuclear Medicine, vol. 25, no. 9, pp. 669–676, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. C. L. Wright, J. D. Werner, J. M. Tran et al., “Radiation pneumonitis following yttrium-90 radioembolization: case report and literature review,” Journal of Vascular and Interventional Radiology, vol. 23, no. 5, pp. 669–674, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Collins and R. Salem, “Hepatic radioembolization complicated by gastrointestinal ulceration,” Seminars in Interventional Radiology, vol. 28, no. 2, pp. 240–245, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Riaz, R. J. Lewandowski, L. M. Kulik et al., “Complications following radioembolization with yttrium-90 microspheres: a comprehensive literature review,” Journal of Vascular and Interventional Radiology, vol. 20, no. 9, pp. 1121–1130, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. X. Rong, Y. Du, and E. C. Frey, “A method for energy window optimization for quantitative tasks that includes the effects of model-mismatch on bias: application to Y-90 bremsstrahlung SPECT imaging,” Physics in Medicine and Biology, vol. 57, no. 12, pp. 3711–3725, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. N. Simon and S. Feitelberg, “Scanning bremsstrahlung of yttrium-90 microspheres injected intra-arterially,” Radiology, vol. 88, no. 4, pp. 719–724, 1967. View at Publisher · View at Google Scholar · View at Scopus
  26. D. Minarik, K. Sjögreen-Gleisner, O. Linden et al., “90Y bremsstrahlung imaging for absorbed-dose assessment in high-dose radioimmunotherapy,” Journal of Nuclear Medicine, vol. 51, no. 12, pp. 1974–1978, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. N. Tehranipour, A. Al-Nahhas, R. Canelo et al., “Concordant F-18 FDG PET and Y-90 Bremsstrahlung scans depict selective delivery of Y-90-microspheres to liver tumors: confirmation with histopathology,” Clinical Nuclear Medicine, vol. 32, no. 5, pp. 371–374, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. M. K. Werner, K. Brechtel, T. Beyer, H. Dittmann, C. Pfannenberg, and J. Kupferschläger, “PET/CT for the assessment and quantification of 90Y biodistribution after selective internal radiotherapy (SIRT) of liver metastases,” European Journal of Nuclear Medicine and Molecular Imaging, vol. 37, no. 2, pp. 407–408, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. L. Strigari, R. Sciuto, S. Rea et al., “Efficacy and toxicity related to treatment of hepatocellular carcinoma with 90Y-SIR spheres: radiobiologic considerations,” Journal of Nuclear Medicine, vol. 51, no. 9, pp. 1377–1385, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. H. Ahmadzadehfar, M. Muckle, A. Sabet et al., “The significance of bremsstrahlung SPECT/CT after yttrium-90 radioembolization treatment in the prediction of extrahepatic side effects,” European Journal of Nuclear Medicine and Molecular Imaging, vol. 39, no. 2, pp. 309–315, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. H. Ahmadzadehfar, A. Sabet, M. Muckle et al., “Tc99m-MAA/90Y-Bremsstrahlung SPECT/CT after simultaneous Tc-MAA/90Y-microsphere injection for immediate treatment monitoring and further therapy planning for radioembolization,” European Journal of Nuclear Medicine and Molecular Imaging, vol. 38, no. 7, pp. 1281–1288, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. S. M. Rhymer, J. A. Parker, and M. R. Palmer, “Detection of 90Y extravasation by bremsstrahlung imaging for patients undergoing 90Y-ibritumomab tiuxetan therapy,” Journal of Nuclear Medicine Technology, vol. 38, no. 4, pp. 195–198, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. S. Shen, G. L. DeNardo, A. Yuan, D. A. DeNardo, and S. J. DeNardo, “Planar gamma camera imaging and quantitation of yttrium-90 bremsstrahlung,” Journal of Nuclear Medicine, vol. 35, no. 8, pp. 1381–1389, 1994. View at Google Scholar · View at Scopus
  34. S. Shen, G. L. DeNardo, and S. J. DeNardo, “Quantitative bremsstrahlung imaging of yttrium-90 using a Wiener filter,” Medical Physics, vol. 21, no. 9, pp. 1409–1417, 1994. View at Publisher · View at Google Scholar · View at Scopus
  35. S. Heard, G. D. Flux, M. J. Guy, and R. J. Ott, “Monte Carlo simulation of Y-90 Bremsstrahlung imaging,” in Proceedings of the 2004 IEEE Nuclear Science Symposium Conference Record, vol. 1–7, pp. 3579–3583, 2004.
  36. S. Walrand, G. D. Flux, M. W. Konijnenberg et al., “Dosimetry of yttrium-labelled radiopharmaceuticals for internal therapy: 86Y or 90Y imaging?” European Journal of Nuclear Medicine and Molecular Imaging, vol. 38, no. 1, pp. S57–S68, 2011. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Elschot, J. F. W. Nijsen, A. J. Dam, and H. W. A. M. de Jong, “Quantitative evaluation of scintillation camera imaging characteristics of isotopes used in liver radioembolization,” PLoS ONE, vol. 6, no. 11, Article ID e26174, 2011. View at Publisher · View at Google Scholar · View at Scopus
  38. D. Minarik, M. Ljungberg, P. Segars, and K. S. Gleisner, “Evaluation of quantitative planar 90Y bremsstrahlung whole-body imaging,” Physics in Medicine and Biology, vol. 54, no. 19, pp. 5873–5883, 2009. View at Publisher · View at Google Scholar · View at Scopus
  39. S. Ito, H. Kurosawa, H. Kasahara et al., “90Y bremsstrahlung emission computed tomography using gamma cameras,” Annals of Nuclear Medicine, vol. 23, no. 3, pp. 257–267, 2009. View at Publisher · View at Google Scholar · View at Scopus
  40. S. Walrand, M. Hesse, G. Demonceau, S. Pauwels, and F. Jamar, “Yttrium-90-labeled microsphere tracking during liver selective internal radiotherapy by bremsstrahlung pinhole SPECT: feasibility study and evaluation in an abdominal phantom,” EJNMMI Research, vol. 1, no. 1, article 32, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. X. Rong, Y. Du, M. Ljungberg, E. Rault, S. Vandenberghe, and E. C. Frey, “Development and evaluation of an improved quantitative 90Y bremsstrahlung SPECT method,” Medical Physics, vol. 39, no. 5, pp. 2346–2358, 2012. View at Publisher · View at Google Scholar · View at Scopus
  42. X. Rong and E. C. Frey, “A collimator optimization method for quantitative imaging: application to Y-90 bremsstrahlung SPECT,” Medical Physics, vol. 40, no. 8, Article ID 082504, 2013. View at Publisher · View at Google Scholar · View at Scopus
  43. X. Rong, M. Ghaly, and E. C. Frey, “Optimization of energy window for 90Y bremsstrahlung SPECT imaging for detection tasks using the ideal observer with model-mismatch,” Medical Physics, vol. 40, no. 6, Article ID 062502, 2013. View at Publisher · View at Google Scholar · View at Scopus
  44. M. Elschot, B. J. Vermolen, M. G. E. H. Lam, B. de Keizer, M. A. A. J. van den Bosch, and H. W. A. M. de Jong, “quantitative comparison of PET and bremsstrahlung SPECT for imaging the in vivo yttrium-90 microsphere Ddistribution after liver radioembolization,” PLoS ONE, vol. 8, no. 2, Article ID e55742, 2013. View at Publisher · View at Google Scholar · View at Scopus
  45. M. Elschot, B. J. Vermolen, M. G. E. H. Lam, B. de Keizer, M. A. A. J. van den Bosch, and H. W. A. M. de Jong, “Quantitative comparison of PET and Bremsstrahlung SPECT for imaging the in vivo yttrium-90 microsphere distribution after liver radioembolization,” PLoS ONE, vol. 8, no. 2, Article ID e55742, 2013. View at Publisher · View at Google Scholar · View at Scopus
  46. A. Goedicke, Y. Berker, F. A. Verburg, F. F. Behrendt, O. Winz, and F. M. Mottaghy, “Study-parameter impact in quantitative 90-yttrium PET imaging for radioembolization treatment monitoring and dosimetry,” IEEE Transactions on Medical Imaging, vol. 32, no. 3, pp. 485–492, 2013. View at Publisher · View at Google Scholar · View at Scopus
  47. C. Fabbri, V. Mattone, M. Casi et al., “Quantitative evaluation on [90Y] DOTATOC PET and SPECT imaging by phantom acquisitions and clinical applications in locoregional and systemic treatments,” The Quarterly Journal of Nuclear Medicine and Molecular Imaging, vol. 56, no. 6, pp. 522–528, 2012. View at Google Scholar · View at Scopus
  48. R. Mansberg, N. Sorensen, V. Mansberg, and H. van der Wall, “Yttrium 90 Bremsstrahlung SPECT/CT scan demonstrating areas of tracer/tumour uptake,” European Journal of Nuclear Medicine and Molecular Imaging, vol. 34, no. 11, p. 1887, 2007. View at Publisher · View at Google Scholar · View at Scopus
  49. P. Flamen, B. Vanderlinden, P. Delatte et al., “Multimodality imaging can predict the metabolic response of unresectable colorectal liver metastases to radioembolization therapy with Yttrium-90 labeled resin microspheres,” Physics in Medicine and Biology, vol. 53, no. 22, pp. 6591–6603, 2008. View at Publisher · View at Google Scholar · View at Scopus
  50. R. Lhommel, P. Goffette, M. van den Eynde et al., “Yttrium-90 TOF PET scan demonstrates high-resolution biodistribution after liver SIRT,” European Journal of Nuclear Medicine and Molecular Imaging, vol. 36, no. 10, p. 1696, 2009. View at Publisher · View at Google Scholar · View at Scopus
  51. Y. H. Kao, E. H. Tan, C. E. Ng, and S. W. Goh, “Yttrium-90 time-of-flight PET/CT is superior to bremsstrahlung SPECT/CT for postradioembolization imaging of microsphere biodistribution,” Clinical Nuclear Medicine, vol. 36, no. 12, pp. e186–e187, 2011. View at Publisher · View at Google Scholar · View at Scopus
  52. M. Vouche, B. Vanderlinden, P. Delatte et al., “New imaging techniques for 90Y microsphere radioembolization,” Journal of Nuclear Medicine & Radiation Therapy, vol. 2, article 113, 2011. View at Publisher · View at Google Scholar
  53. Y. H. Kao, E. H. Tan, K. Y. Lim, C. E. Ng, and S. W. Goh, “Yttrium-90 internal pair production imaging using first generation PET/CT provides high-resolution images for qualitative diagnostic purposes,” The British Journal of Radiology, vol. 85, no. 1015, pp. 1018–1019, 2012. View at Publisher · View at Google Scholar · View at Scopus
  54. T. Carlier, T. Eugène, C. Bodet-Milin et al., “Assessment of acquisition protocols for routine imaging of Y-90 using PET/CT,” EJNMMI Research, vol. 3, no. 1, article 11, 2013. View at Publisher · View at Google Scholar · View at Scopus
  55. M. Elschot, M. G. E. H. Lam, M. A. A. J. van den Bosch, M. A. Viergever, and H. W. A. M. de Jong, “Quantitative Monte Carlo-based 90Y SPECT reconstruction,” Journal of Nuclear Medicine, vol. 54, no. 9, pp. 1557–1563, 2013. View at Publisher · View at Google Scholar · View at Scopus
  56. G. Ulrich, O. Dudeck, C. Furth et al., “Predictive value of intratumoral Tc99m-macroaggregated albumin uptake in patients with colorectal liver metastases scheduled for radioembolization with 90Y-microspheres,” Journal of Nuclear Medicine, vol. 54, no. 4, pp. 516–522, 2013. View at Publisher · View at Google Scholar · View at Scopus
  57. M. Wondergem, M. L. J. Smits, M. Elschot et al., “99mTc-macroaggregated albumin poorly predicts the intrahepatic distribution of 90-Y resin microspheres in hepatic radioembolization,” Journal of Nuclear Medicine, vol. 54, no. 8, pp. 1294–1301, 2013. View at Google Scholar
  58. Y. H. Kao, A. E. H. Tan, R. H. G. Lo et al., “Non-target activity detection by post-radioembolization yttrium-90 PET/CT: image assessment technique and case examples,” Frontiers in Oncology, vol. 4, article 11, 2014. View at Publisher · View at Google Scholar · View at Scopus
  59. B. R. Eaton, H. S. Kim, E. Schreibmann et al., “Quantitative dosimetry for yttrium-90 radionuclide therapy: tumor dose predicts fluorodeoxyglucose positron emission tomography response in hepatic metastatic melanoma,” Journal of Vascular and Interventional Radiology, vol. 25, no. 2, pp. 288–295, 2014. View at Publisher · View at Google Scholar · View at Scopus
  60. N. Kokabi, J. R. Galt, M. Xing et al., “A simple method for estimating dose delivered to hepatocellular carcinoma after yttrium-90 glass-based radioembolization therapy: preliminary results of a proof of concept study,” Journal of Vascular and Interventional Radiology, vol. 25, no. 2, pp. 277–287, 2014. View at Publisher · View at Google Scholar · View at Scopus
  61. S. A. Padia, A. Alessio, S. W. Kwan, D. H. Lewis, S. Vaidya, and S. Minoshima, “Comparison of positron emission tomography and bremsstrahlung imaging to detect particle distribution in patients undergoing yttrium-90 radioembolization for large hepatocellular carcinomas or associated portal vein thrombosis,” Journal of Vascular and Interventional Radiology, vol. 24, no. 8, pp. 1147–1153, 2013. View at Publisher · View at Google Scholar · View at Scopus
  62. M. Wissmeyer, S. Heinzer, P. Majno et al., “90Y time-of-flight PET/MR on a hybrid scanner following liver radioembolisation (SIRT),” European Journal of Nuclear Medicine and Molecular Imaging, vol. 38, no. 9, pp. 1744–1745, 2011. View at Publisher · View at Google Scholar · View at Scopus
  63. T. C. Lauenstein, T. A. Heusner, M. Hamami et al., “Radioembolization of hepatic tumors: flow redistribution after the occlusion of intrahepatic arteries,” RöFo—Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, vol. 183, no. 11, pp. 1058–1064, 2011. View at Publisher · View at Google Scholar · View at Scopus
  64. A. Gupta, A. Gill, S. Shrikanthan, and S. Srinivas, “Nontargeted Y-90 microsphere radioembolization to duodenum visualized on Y-90 PET/CT and Bremsstrahlung SPECT/CT,” Clinical Nuclear Medicine, vol. 37, no. 1, pp. 98–99, 2012. View at Publisher · View at Google Scholar · View at Scopus
  65. W. A. Dezarn, J. T. Cessna, L. A. Dewerd et al., “Recommendations of the American Association of Physicists in Medicine on dosimetry, imaging, and quality assurance procedures for 90Y microsphere brachytherapy in the treatment of hepatic malignancies,” Medical Physics, vol. 38, no. 8, pp. 4824–4845, 2011. View at Publisher · View at Google Scholar · View at Scopus
  66. R. J. Nickles, A. D. Roberts, J. A. Nye et al., “Assaying and PET imaging of ytrrium-90: 134ppm>0,” in Proceedings of the IEEE Nuclear Science Symposium Conference Record, vol. 6, pp. 3412–3414, IEEE, October 2004. View at Publisher · View at Google Scholar
  67. R. G. Selwyn, R. J. Nickles, B. R. Thomadsen, L. A. DeWerd, and J. A. Micka, “A new internal pair production branching ratio of 90Y: the development of a non-destructive assay for 90Y and 90Sr,” Applied Radiation and Isotopes, vol. 65, no. 3, pp. 318–327, 2007. View at Publisher · View at Google Scholar · View at Scopus
  68. M. D'Arienzo, “Emission of β+ particles via internal pair production in the 0+-0+ transition of 90Zr: historical background and current applications in nuclear medicine imaging,” Atoms, vol. 1, no. 1, pp. 2–12, 2013. View at Publisher · View at Google Scholar
  69. R. Lhommel, L. van Elmbt, P. Goffette et al., “Feasibility of 90Y TOF PET-based dosimetry in liver metastasis therapy using SIR-Spheres,” European Journal of Nuclear Medicine and Molecular Imaging, vol. 37, no. 9, pp. 1654–1662, 2010. View at Publisher · View at Google Scholar · View at Scopus
  70. K. Willowson, N. Forwood, B. W. Jakoby, A. M. Smith, and D. L. Bailey, “Quantitative 90Y image reconstruction in PET,” Medical Physics, vol. 39, no. 11, pp. 7153–7159, 2012. View at Publisher · View at Google Scholar · View at Scopus
  71. L. van Elmbt, S. Vandenberghe, S. Walrand, S. Pauwels, and F. Jamar, “Comparison of yttrium-90 quantitative imaging by TOF and non-TOF PET in a phantom of liver selective internal radiotherapy,” Physics in Medicine and Biology, vol. 56, no. 21, pp. 6759–6777, 2011. View at Publisher · View at Google Scholar · View at Scopus
  72. O. Bagni, M. D'Arienzo, P. Chiaramida et al., “90Y-PET for the assessment of microsphere biodistribution after selective internal radiotherapy,” Nuclear Medicine Communications, vol. 33, no. 2, pp. 198–204, 2012. View at Publisher · View at Google Scholar · View at Scopus
  73. M. D'Arienzo, P. Chiaramida, L. Chiacchiararelli et al., “90Y PET-based dosimetry after selective internal radiotherapy treatments,” Nuclear Medicine Communications, vol. 33, no. 6, pp. 633–640, 2012. View at Publisher · View at Google Scholar · View at Scopus
  74. T. T. Chang, A. C. Bourgeois, A. M. Balius, and A. S. Pasciak, “Treatment modification of yttrium-90 radioembolization based on quantitative positron emission tomography/CT imaging,” Journal of Vascular and Interventional Radiology, vol. 24, no. 3, pp. 333–337, 2013. View at Publisher · View at Google Scholar · View at Scopus
  75. Y.-H. Kao, J. D. Steinberg, Y.-S. Tay et al., “Post-radioembolization yttrium-90 PET/CT—part 2: dose-response and tumor predictive dosimetry for resin microspheres,” EJNMMI Research, vol. 3, no. 1, article 57, 2013. View at Publisher · View at Google Scholar · View at Scopus
  76. A. C. Bourgeois, T. T. Chang, Y. C. Bradley, S. N. Acuff, and A. S. Pasciak, “Intraprocedural yttrium-90 positron emission tomography/CT for treatment optimization of yttrium-90 radioembolization,” Journal of Vascular and Interventional Radiology, vol. 25, no. 2, pp. 271–275, 2014. View at Publisher · View at Google Scholar · View at Scopus
  77. A. F. van den Hoven, J. F. Prince, M. Samim et al., “Posttreatment PET-CT-confirmed intrahepatic radioembolization performed without coil embolization, by using the antireflux surefire infusion system,” CardioVascular and Interventional Radiology, vol. 37, no. 2, pp. 523–528, 2014. View at Publisher · View at Google Scholar · View at Scopus
  78. V. L. Gates, A. A. H. Esmail, K. Marshall, S. Spies, and R. Salem, “Internal pair production of 90Y permits hepatic localization of microspheres using routine PET: proof of concept,” Journal of Nuclear Medicine, vol. 52, no. 1, pp. 72–76, 2011. View at Publisher · View at Google Scholar · View at Scopus
  79. M. D. Mamawan, S. C. Ong, and J. M. Senupe, “Post-90Y radioembolization PET/CT scan with respiratory gating using time-of-flight reconstruction,” Journal of Nuclear Medicine Technology, vol. 41, no. 1, p. 42, 2013. View at Publisher · View at Google Scholar · View at Scopus
  80. S. Walrand, F. Jamar, L. van Elmbt, R. Lhommel, E. B. Bekonde, and S. Pauwels, “4-step renal dosimetry dependent on cortex geometry applied to 90Y peptide receptor radiotherapy: evaluation using a fillable kidney phantom imaged by 90Y PET,” Journal of Nuclear Medicine, vol. 51, no. 12, pp. 1969–1973, 2010. View at Publisher · View at Google Scholar
  81. J. P. Holland, G. Normand, A. Ruggiero, J. S. Lewis, and J. Grimm, “Intraoperative imaging of positron emission tomographic radiotracers using cerenkov luminescence emissions,” Molecular Imaging, vol. 10, no. 3, pp. 177–186, 2011. View at Publisher · View at Google Scholar · View at Scopus
  82. R. Robertson, M. S. Germanos, C. Li, G. S. Mitchell, S. R. Cherry, and M. D. Silva, “Optical imaging of Cerenkov light generation from positron-emitting radiotracers,” Physics in Medicine and Biology, vol. 54, no. 16, pp. N355–N365, 2009. View at Publisher · View at Google Scholar · View at Scopus
  83. A. E. Spinelli, D. D'Ambrosio, L. Calderan, M. Marengo, A. Sbarbati, and F. Boschi, “Cerenkov radiation allows in vivo optical imaging of positron emitting radiotracers,” Physics in Medicine and Biology, vol. 55, no. 2, pp. 483–495, 2010. View at Publisher · View at Google Scholar · View at Scopus
  84. D. Thorek, R. Robertson, W. A. Bacchus et al., “Cerenkov imaging—a new modality for molecular imaging,” American Journal of Nuclear Medicine and Molecular Imaging, vol. 2, no. 2, pp. 163–173, 2012. View at Google Scholar
  85. H. Liu, G. Ren, Z. Miao et al., “Molecular optical imaging with radioactive probes,” PLoS ONE, vol. 5, no. 3, Article ID e9470, 2010. View at Publisher · View at Google Scholar · View at Scopus
  86. A. Ruggiero, J. P. Holland, J. S. Lewis, and J. Grimm, “Cerenkov luminescence imaging of medical isotopes,” Journal of Nuclear Medicine, vol. 51, no. 7, pp. 1123–1130, 2010. View at Publisher · View at Google Scholar · View at Scopus
  87. Y. Xu, H. Liu, and Z. Cheng, “Harnessing the power of radionuclides for optical imaging: cerenkov luminescence imaging,” Journal of Nuclear Medicine, vol. 52, no. 12, pp. 2009–2018, 2011. View at Publisher · View at Google Scholar · View at Scopus
  88. D. Satpati, S. H. Hausner, N. Bauer, and J. L. Sutcliffe, “Cerenkov luminescence imaging of αvβ6 integrin expressing tumors using (90) Y-labeled peptides,” Journal of Labelled Compounds & Radiopharmaceuticals, vol. 57, no. 9, pp. 558–565, 2014. View at Publisher · View at Google Scholar
  89. A. E. Spinelli, M. Ferdeghini, C. Cavedon et al., “First human cerenkography,” Journal of Biomedical Optics, vol. 18, no. 2, Article ID 020502, 2013. View at Publisher · View at Google Scholar · View at Scopus
  90. S. Walrand, M. Hesse, R. Wojcik, R. Lhommel, and F. Jamar, “Optimal design of anger camera for bremsstrahlung imaging: monte carlo evaluation,” Frontiers in Oncology, vol. 4, article 149, 2014. View at Publisher · View at Google Scholar
  91. M. D’Arienzo, M. Capogni, V. Smyth et al., “Metrological issues in molecular radiotherapy,” EPJ Web of Conferences, vol. 77, Article ID 00022, 2014. View at Publisher · View at Google Scholar
  92. V. Lourenço, C. Bobin, V. Chisté et al., “Primary standardization of SIR-Spheres based on the dissolution of the 90Y-labeled resin microspheres,” Applied Radiation and Isotopes, vol. 97, pp. 170–176, 2015. View at Publisher · View at Google Scholar
  93. D. Y. Lee and K. C. P. Li, “Molecular theranostics: a primer for the imaging professional,” American Journal of Roentgenology, vol. 197, no. 2, pp. 318–324, 2011. View at Publisher · View at Google Scholar · View at Scopus