Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015, Article ID 481621, 10 pages
Research Article

Serum Levels of ApoA1 and ApoA2 Are Associated with Cognitive Status in Older Men

1Department of Geriatrics, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China
2Department of Aging, Antiaging and Cognitive Function, Shanghai Institute of Geriatrics and Gerontology, Shanghai 200040, China
3Research Center of Aging and Medicine, Department of Aging and Shanghai Key Laboratory of Clinical Geriatrics, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China

Received 15 August 2015; Revised 4 November 2015; Accepted 8 November 2015

Academic Editor: Wiep Scheper

Copyright © 2015 Cheng Ma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Advancing age, chronic inflammation, oxidative damage, and disorders of lipid metabolism are positively linked to the late-life cognitive impairment. Serum biomarkers may be associated with the cognitive status in older men. Methods. 440 old male subjects with different cognitive functions were recruited to investigate probable serum markers. Pearson Chi-Squared test, univariate analysis, and multivariate logistic regression analysis were performed to evaluate biomarkers which may be associated with cognitive status. Results. Levels of fundus atherosclerosis (AS) (), age (), serum biomarkers peroxidase (POD) () and interleukin-6 (IL-6) (), serum levels of high-density lipoprotein cholesterol (HDL-C) (), apolipoprotein A2 (ApoA2) (), and ApoC2 () showed significant differences. Compared to group 3, ApoA1 in group 1 (OR = 1.30, 95% CI 1.01–1.67) and group 2 (OR = 1.47, 95% CI 1.11–1.94) were higher, while ApoA2 were lower (group 1: OR = 0.43, 95% CI 0.18–1.02; group 2: OR = 0.21, 95% CI 0.08–0.54) after adjusting for control variables. Conclusion. The results demonstrated that age, AS levels, POD, IL-6, HDL-C, ApoA2, and ApoC2 were significantly related to cognitive status. Moreover, ApoA1 and ApoA2 were independently associated with cognitive impairment and late-life dementia.