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BioMed Research International
Volume 2015 (2015), Article ID 483726, 7 pages
http://dx.doi.org/10.1155/2015/483726
Research Article

Statistical Genomic Approach Identifies Association between FSHR Polymorphisms and Polycystic Ovary Morphology in Women with Polycystic Ovary Syndrome

1Department of Gynecology & Obstetrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 West Yanjiang Road, Guangzhou 510120, China
2Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

Received 12 January 2015; Accepted 13 February 2015

Academic Editor: Xiao Chang

Copyright © 2015 Tao Du et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Azziz, K. S. Woods, R. Reyna, T. J. Key, E. S. Knochenhauer, and B. O. Yildiz, “The prevalence and features of the polycystic ovary syndrome in an unselected population,” The Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 6, pp. 2745–2749, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group, “Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS),” Human Reproduction, vol. 19, no. 1, pp. 41–47, 2004. View at Publisher · View at Google Scholar
  3. M. O. Goodarzi, D. A. Dumesic, G. Chazenbalk, and R. Azziz, “Polycystic ovary syndrome: etiology, pathogenesis and diagnosis,” Nature Reviews Endocrinology, vol. 7, no. 4, pp. 219–231, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. J. J. Kim, K. R. Hwang, Y. M. Choi et al., “Complete phenotypic and metabolic profiles of a large consecutive cohort of untreated Korean women with polycystic ovary syndrome,” Fertility and Sterility, vol. 101, no. 5, pp. 1424–1430, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. N. M. Clark, A. J. Podolski, E. D. Brooks et al., “Prevalence of polycystic ovary syndrome phenotypes using updated criteria for polycystic ovarian morphology: an assessment of over 100 consecutive women self-reporting features of polycystic ovary syndrome,” Reproductive Sciences, vol. 21, no. 8, pp. 1034–1043, 2014. View at Publisher · View at Google Scholar
  6. Y. Shi, H. Zhao, Y. Cao et al., “Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome,” Nature Genetics, vol. 44, no. 9, pp. 1020–1025, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. R. González-Fernández, Ó. Peña, J. Hernández, P. Martín-Vasallo, A. Palumbo, and J. Ávila, “Patients with endometriosis and patients with poor ovarian reserve have abnormal follicle-stimulating hormone receptor signaling pathways,” Fertility and Sterility, vol. 95, no. 7, pp. 2373–2378, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. B.-H. Gu, J.-M. I. Park, and K.-H. Baek, “Genetic variations of follicle stimulating hormone receptor are associated with polycystic ovary syndrome,” International Journal of Molecular Medicine, vol. 26, no. 1, pp. 107–112, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. L. Sun, Y. Peng, A. C. Sharrow et al., “FSH Directly Regulates Bone Mass,” Cell, vol. 125, no. 2, pp. 247–260, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. B. O. Yildiz, S. Bolour, K. Woods, A. Moore, and R. Azziz, “Visually scoring hirsutism,” Human Reproduction Update, vol. 16, no. 1, pp. 51–64, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. G. Plewig, “Classification of acne vulgaris,” in Acne: Morphogenesis and Treatment, Springer, Berlin, Germany, 1975. View at Google Scholar
  12. M. Simoni, J. Gromoll, and E. Nieschlag, “The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology,” Endocrine Reviews, vol. 18, no. 6, pp. 739–773, 1997. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Catteau-Jonard, S. P. Jamin, A. Leclerc, J. Gonzalès, D. Dewailly, and N. Di Clemente, “Anti-Mullerian hormone, its receptor, FSH receptor, and androgen receptor genes are overexpressed by granulosa cells from stimulated follicles in women with polycystic ovary syndrome,” Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 11, pp. 4456–4461, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Durlej, K. Knapczyk-Stwora, M. Duda, J. Galas, and M. Slomczynska, “The expression of FSH receptor (FSHR) in the neonatal porcine ovary and its regulation by flutamide,” Reproduction in Domestic Animals, vol. 46, no. 3, pp. 377–384, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. A. P. N. Themmen and I. T. Huhtaniemi, “Mutations of gonadotropins and gonadotropin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function,” Endocrine Reviews, vol. 21, no. 5, pp. 551–583, 2000. View at Publisher · View at Google Scholar · View at Scopus
  16. T. Minegish, K. Nakamura, Y. Takakura, Y. Ibuki, and M. Igarashi, “Cloning and sequencing of human FSH receptor cDNA,” Biochemical and Biophysical Research Communications, vol. 175, no. 3, pp. 1125–1130, 1991. View at Publisher · View at Google Scholar · View at Scopus
  17. C. K. Bose, “Follicle stimulating hormone receptor in ovarian surface epithelium and epithelial ovarian cancer,” Oncology Research, vol. 17, no. 5, pp. 231–238, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. J. H. Yun, B.-H. Gu, Y.-B. Kang, B.-C. Choi, S. Song, and K.-H. Baek, “Association between INS-VNTR polymorphism and polycystic ovary syndrome in a Korean population,” Gynecological Endocrinology, vol. 28, no. 7, pp. 525–528, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Yang, H. Gong, W. Liu, and T. Tao, “The association of Pro12ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 gene with the metabolic characteristics in chinese women with polycystic ovary syndrome,” International Journal of Clinical and Experimental Pathology, vol. 6, no. 9, pp. 1894–1902, 2013. View at Google Scholar · View at Scopus
  20. A. Ben-Salem, M. Ajina, M. Suissi, H. S. Daher, W. Y. Almawi, and T. Mahjoub, “Polymorphisms of transcription factor-7-like 2 (TCF7L2) gene in Tunisian women with polycystic ovary syndrome (PCOS),” Gene, vol. 533, no. 2, pp. 554–557, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. D. J. Chen, R. Ding, J. Y. Cao, J. X. Zhai, J. X. Zhang, and D. Q. Ye, “Two follicle-stimulating hormone receptor polymorphisms and polycystic ovary syndrome risk: a meta-analysis,” European Journal of Obstetrics & Gynecology and Reproductive Biology, vol. 182, pp. 27–32, 2014. View at Publisher · View at Google Scholar
  22. L. Li, X. Chen, Z. He, X. Zhao, L. Huang, and D. Yang, “Clinical and metabolic features of polycystic ovary syndrome among Chinese adolescents,” Journal of Pediatric and Adolescent Gynecology, vol. 25, no. 6, pp. 390–395, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Jonard and D. Dewailly, “The follicular excess in polycystic ovaries, due to intra-ovarian hyperandrogenism, may be the main culprit for the follicular arrest,” Human Reproduction Update, vol. 10, no. 2, pp. 107–117, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. K. A. Vendola, J. Zhou, O. O. Adesanya, S. J. Weil, and C. A. Bondy, “Androgens stimulate early stages of follicular growth in the primate ovary,” Journal of Clinical Investigation, vol. 101, no. 12, pp. 2622–2629, 1998. View at Publisher · View at Google Scholar · View at Scopus
  25. N. Xita and A. Tsatsoulis, “Review: fetal programming of polycystic ovary syndrome by androgen excess: Evidence from experimental, clinical, and genetic association studies,” Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 5, pp. 1660–1666, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. S. Catteau-Jonard and D. Dewailly, “Pathophysiology of polycystic ovary syndrome: the role of hyperandrogenism,” Frontiers of Hormone Research, vol. 40, pp. 22–27, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. B. C. J. M. Fauser, T. D. Pache, S. W. J. Lamberts, W. C. J. Hop, F. H. de Jong, and K. D. Dahl, “Serum bioactive and immunoreactive luteinizing hormone and follicle-stimulating hormone levels in women with cycle abnormalities, with or without polycystic ovarian disease,” Journal of Clinical Endocrinology and Metabolism, vol. 73, no. 4, pp. 811–817, 1991. View at Publisher · View at Google Scholar · View at Scopus