Bypassing P-Glycoprotein Drug Efflux Mechanisms: Possible Applications in Pharmacoresistant Schizophrenia Therapy

Table 2

Brief overview of P-gp inhibitors/substrates and the corresponding IC₅₀ values of inhibitors.

Inhibitor	IC50	References
Haloperidol	Potent	[105]
Fluoxetine; Chlorpromazine; Paroxetine; Sertraline	Moderate	[59, 105]
Risperidone; 9-hydroxyrisperidone; Sulpiride; Zolpidem	Low	[59, 105]
Loperamide		[59]
Verapamil; Quinidine	Moderate	[58, 59]
Prednisone	Low	[59]

Potent (P) inhibition (IC₅₀ < 10 M), moderate (M) inhibition (10 M ≤ IC₅₀ < 50 M), and low (L) inhibition (IC₅₀ ≥ 50 M). Non-CNS Inhibitors.