Bypassing P-Glycoprotein Drug Efflux Mechanisms: Possible Applications in Pharmacoresistant Schizophrenia Therapy
Table 3
Summarized list of polymer & surfactant P-gp inhibitors and their mechanism of action.
Polymer and surfactant based P-gp efflux inhibitors
Applications
References
Natural polymers:
Xanthan gum Gellan gum Alginates
Inhibition of the P-gp efflux transporter by the presence of polysaccharide d-mannose monomers, increasing concentration of substrates, for example, vinblastine and doxorubicin.