Prognostic Significance of Serum Inflammatory Response Markers in Newly Diagnosed Non-Small Cell Lung Cancer before Chemoirradiation
Table 1
Distribution of 100 participants according to the expression of Alb and CRP.
Variables
Alb expression
value
CRP expression
value
Low expression
High expression
Low expression
High expression
()
()
()
()
Age, years
71.58 ± 10.11
64.92 ± 10.66
0.002†
66.34 ± 9.52
70.42 ± 11.77
0.060†
PS
0.036††
0.009†††
0-1
38 (73.1)
43 (89.6)
46 (92.0)
35 (70.0)
2–4
14 (26.9)
5 (10.4)
4 (8.0)
15 (30.0)
Smoking
0.439†††
0.99†††
No
5 (9.6)
2 (4.2)
3 (6.0)
4 (8.0)
Smokers
47 (90.4)
46 (95.8)
47 (94.0)
46 (92.0)
ETOH
0.275††
0.99††
Social
24 (46.2)
17 (35.4)
20 (40.0)
21 (42.0)
Heavy
28 (53.8)
31 (64.6)
30 (60.0)
29 (58.0)
INF
0.894††
0.99††
No
47 (90.4)
43 (89.6)
45 (90.0)
45 (90.0)
Yes
5 (9.6)
5 (10.4)
5 (10.0)
5 (10.0)
LVI
0.894††
0.009†††
No
47 (90.4)
43 (89.6)
46 (92.0)
35 (70.0)
Yes
5 (9.6)
5 (10.4)
4 (8.0)
15 (30.0)
NEC
0.108††
0.68††
No
42 (80.8)
32 (66.7)
33 (66.0)
41 (82.0)
Yes
10 (19.2)
5 (10.4)
17 (34.0)
9 (18.0)
FIB
0.149†††
0.059†††
No
42 (80.8)
32 (66.7)
43 (86.0)
49 (98.0)
Yes
10 (19.2)
5 (10.4)
7 (14.0)
1 (2.0)
TNM stage
0.012††
<0.001††
I and II
8 (15.4)
18 (37.5)
21 (42.0)
5 (10.0)
III and IV
44 (84.6)
30 (62.5)
29 (58.0)
45 (90.0)
Histological grade
0.005††
<0.001††
I and II
20 (38.5)
32 (66.7)
39 (78.0)
13 (26.0)
III and IV
32 (64.5)
16 (33.3)
11 (22.0)
37 (74.0)
OS
12.09 ± 11.83
20.90 ± 19.04
0.007†
22.92 ± 9.73
19.85 ± 7.07
<0.001†
PS = performance status, ETH = alcohol, INF = inflammation, LVI = lymphovascular invasion, NEC = necrosis, FIB = fibrosis, and OS = overall survival. Data are presented as (%) or mean ± standard deviation. Bonferroni-Holm correction was applied to compare differences between groups. value derived from Student’s -test, value derived from Chi-square test, and value derived from Fisher’s Exact test.
