BRAF Testing in Multifocal Papillary Thyroid Carcinoma
Table 1
Patient characteristics.
Patient number
Age
Sex
Months of Followup
Initial pTN
Number of nodules
Size of largest nodule (cm)
Histologic variant of largest nodule
BRAF status of largest nodule
Size of second-largest nodule (cm)
Histologic variant of second-largest nodule
BRAF status of second-largest nodule
1
40
F
34
T1b N1a
4
1.4
Fol
Positive
0.8
Fol
Positive
2
64
M
40
T3 N1b
2
1.2
TC
Positive
0.5
Clas
Positive
3
74
M
1
T3 N1b
4
1.1
Clas
Positive
0.3
Clas
Positive
4*
58
M
13
T3 N1b
2
1.3
Clas
Positive
0.4
Fol
Positive
5
65
M
2
T1a N1a
5
1.0
Clas
Positive
0.9
Clas
Positive
6
78
M
9
T1a N0
4
0.5
Clas
Positive
0.2
Clas
Positive
7
55
F
29
T2 N0
6
2.5
TC
Positive
0.4
War
Positive
8
59
F
4
T1b N1b
2
1.5
Fol
Positive
0.2
Fol
Positive
9*
50
M
50
T1a N0
3
0.9
Clas
Positive
0.8
Clas
Positive
10
28
F
6
T3 N1a
8
2.2
Clas
Positive
2.2
Clas
Positive
11
63
M
3
T1b N1a
2
1.2
Clas
Positive
0.2
Fol
Positive
12
26
F
3
T1b N1a
2
1.4
Clas
Positive
0.3
Fol
Positive
13
43
M
23
T2 N1b
3
3.6
TC
Positive
0.2
Fol
Negative
14
50
F
22
T3 N0
3
0.4
Clas
Positive
0.1
Fol
Negative
15
42
F
22
T2 N1a
2
2.6
Clas
Positive
0.2
Clas
Negative
16
44
F
11
T1a N0
2
0.7
Onc
Positive
0.4
Onc
Negative
17
37
F
10
T1a N0
2
1.0
Clas
Negative
0.3
Clas
Positive
18
45
F
8
T2 N0
9
2.4
Fol
Negative
0.5
Fol
Positive
19‡
49
F
56
T2 N0
2
2.4
Fol
Negative
0.6
Fol
Positive
20
53
M
6
T2 N0
2
2.4
Fol
Negative
0.2
Fol
Positive
21
49
F
20
T1a N0
2
0.2
Fol
Negative
0.1
Fol
Positive
22
76
F
1
T3 N0
2
1.2
Fol
Negative
0.9
Clas
Positive
23
53
F
79
T3 N0
2
2.0
Fol
Negative
2.0
Fol
Negative
24**
32
F
4
T1b N1b
4
2.0
Clas
Negative
0.2
Clas
Negative
25**
67
F
<1
T1b N1a
5
1.1
Onc
Negative
0.2
Fol
Negative
26
48
F
81
T2 N0
2
3.5
Fol
Negative
0.7
Fol
Negative
27
60
M
<1
T1b N0
2
1.9
Fol
Negative
0.5
Fol
Negative
The indicates that the patient experienced a recurrence (Patient 4 at 7 months postsurgery/3 months post-radioactive iodine and Patient 9 at 19 months postsurgery/16 months post-radioactive iodine). The ‡ indicates a patient who had a possible recurrence that could not be biopsied and was treated with radioiodine. The indicates that additional tumors were tested for these patients (Patient 24: two additional nodules, Patient 25: one additional nodule); the additional nodules were all negative. Fol = follicular variant, TC = tall cell variant, Clas = classic variant, Onc = oncocytic variant, War = Warthin-like variant.
