Evaluation of Single-Impact-Induced Cartilage Degeneration by Optical Coherence Tomography
(a) Top view of a representative cartilage sample to illustrate the standardized scan area. Tissue marking dye spots at the 12, 6, and 9 o’clock positions indicate the midsagittal plane (between 12 and 6 o’clock) and its perpendicular plane, while the intersection point between both planes is the sample centre point (1; white spot). From here, 3D OCT scanning was performed parallel to the midsagittal plane in an area of 10 × 10 mm (length width) towards the sample periphery as indicated by 9 o’clock dot (2; parallel lines within box). Thus, the impact area itself (3; centered on the centre point) and the immediate adjacent concentric tissue were scanned. (b) Corresponding histological section demonstrating the topography of the sample centre point (1) and the scan area (2) in relation to the radius of the impact area (3). Note the absence of subchondral cancellous bone which had been removed to leave only compact bone attached. Safranin O, 1.6x magnification.
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