Evaluation of Single-Impact-Induced Cartilage Degeneration by Optical Coherence Tomography

Table 2

Summary of histology- and OCT-based grading of human cartilage degeneration following standardized impact with low (LIMP), moderate (MIMP), or high (HIMP) energy. Scoring of degenerative changes was performed according to the Degenerative Joint Disease (DJD) classification or the proteoglycan content subscore of the Mankin classification. Nonparametric Kruskal-Wallis test followed by Dunn’s post hoc testing was performed for statistical analyses. Data are presented as M ± SD; . Dunn’s posttesting revealed controls versus HIMP (histological DJD) and all groups versus HIMP (OCT DJD) to be significantly different. It is of note that one sample in the control group was lost during the histological preparation ( = 9).

	Controls	LIMP	MIMP	HIMP	value
Proteoglycan content (histology)	0.74 ± 0.51; 9	0.79 ± 0.43; 8	0.88 ± 0.7; 8	1.73 ± 0.91; 8	0.046 []
DJD grade (histology)	0.98 ± 0.59; 9	1.12 ± 0.49; 8	1.30 ± 1.06; 8	2.62 ± 1.3; 8	0.025 []
DJD grade (OCT)	0.73 ± 0.60; 9	1.02 ± 0.48; 8	1.00 ± 0.61; 8	2.65 ± 0.86; 8	<0.001 []

]: 0.01 ≤ ≤ 0.05; []: < 0.001.