Arctigenin, a Potent Ingredient of Arctium lappa L., Induces Endothelial Nitric Oxide Synthase and Attenuates Subarachnoid Hemorrhage-Induced Vasospasm through PI3K/Akt Pathway in a Rat Model

Figure 3

Bar graph depicting Arctigenin on the change eNOS after induction of SAH. Upper panel: NOS immunostaining (arrowhead), the groups are depicted as (a) healthy control, (b) SAH-only and SAH rats receiving, (c) 75 μM/Kg, (d) 150 μM/Kg, and (e) 450 μM/Kg Arctigenin treatment. The effect of Arctigenin is relevant to eNOs dose-dependently. Data in the figure are presented as mean ± SD (). ^☆, compared the Sham-operated to the SAH group; , and ^# when compared with the SAH + vehicle group.