A Novel Anti-Histone H1 Monoclonal Antibody, SSV Monoclonal Antibody, Improves Lung Injury and Survival in a Mouse Model of Lipopolysaccharide-Induced Sepsis-Like Syndrome

Figure 3

Histones H1, H3, and H4 levels in plasma and lung tissue. (a) Plasma histone H1 levels in the control and SSV mAb groups at the time of LPS injection and 3, 6, 9, 12, and 24 hr later were measured by ELISA and then normalized to the level measured at the time of LPS injection. Values plotted are means ± standard deviation. ^*Statistically significant differences (). (b) Plasma histone H3 levels in mice. (c) Plasma histone H4 levels in mice. (d) Histone H1 levels in lung tissue in the control and SSV mAb groups at the time of LPS injection and then 3, 6, 9, 12, and 24 hr later were measured by ELISA and then normalized to the level measured at the time of LPS injection. Values plotted are means ± standard deviation. ^*Statistically significant differences (). (e) Histone H3 levels in lung tissue. (f) Histone H4 levels in lung tissue.

(a) Plasma level of histone H1

(b) Plasma level of histone H3

(c) Plasma level of histone H4

(d) Histone H1 in lung tissue

(e) Histone H3 in lung tissue

(f) Histone H4 in lung tissue