A Novel Anti-Histone H1 Monoclonal Antibody, SSV Monoclonal Antibody, Improves Lung Injury and Survival in a Mouse Model of Lipopolysaccharide-Induced Sepsis-Like Syndrome

Figure 5

Effect of SSV mAb on plasma cytokine levels. (a) Plasma TNF-α levels in the control (dashed line) and SSV mAb (solid line) groups at the time of LPS injection and then 3, 6, 9, 12, and 24 hr later ( per time point) were measured by ELISA. Values plotted are means ± standard deviation. ^*Statistically significant differences (). (b) Plasma IL-1β levels in the control (dashed line) or SSV mAb (solid line) groups at the time of LPS injection and then 3, 6, 9, 12, and 24 hr later ( per time point) were measured by ELISA. Values plotted are means ± standard deviation. ^*Statistically significant differences (). (c) Plasma IL-6 levels in the control (dashed line) and SSV mAb (solid line) groups at the time of LPS injection and then 3, 6, 9, 12, and 24 hr later ( per time point). Values plotted are means ± standard deviation. ^*Statistically significant differences (). (d) Plasma IL-10 levels in the control (dashed line) and SSV mAb (solid line) groups at the time of LPS injection and then 3, 6, 9, 12, and 24 hr later ( per time point). Values plotted are means ± standard deviation. ^*Statistically significant differences ().

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