Vitamin D Binding Protein Is Not Involved in Vitamin D Deficiency in Patients with Chronic Kidney Disease
Table 1
Characteristics of study subjects.
Healthy controls (C)
Chronic kidney disease (CKD)
Long-term haemodialysis (HD)
Significance
Body mass index (kg/m2)
26.13 ± 4.28
26.84 ± 5.18
27.07 ± 5.34
n.s.
S-Creatinine (umol/L)
91 ± 12
292 ± 148
777 ± 219
< 0.0001 C versus CKD*** C versus HD**** CKD versus HD****
Haemoglobin (g/L)
143 ± 9
120 ± 14
112 ± 11
< 0.0001 C versus CKD**** C versus HD**** CKD versus HD***
Albumin (g/L)
47.3 ± 3.4
41.4 ± 5.0
40.9 ± 3.3
< 0.0001 C versus CKD**** C versus HD**** CKD versus HD n.s.
Calcium (mmol/L)
2.32 ± 0.11
2.28 ± 0.25
2.16 ± 0.18
< 0.0001 C versus CKD n.s. C versus HD*** CKD versus HD**
Phosphate (mmol/L)
1.13 ± 0.20
1.19 ± 0.30
1.95 ± 0.57
< 0.0001 C versus CKD n.s. C versus HD**** CKD versus HD****
Parathyroid hormone (pmol/L)
4.21 ± 2.26 3.73 (3.02–4.75)
14.03 ± 14.43 9.60 (5.15–16.73)
34.57 ± 35.81 23.97 (14.60–41.05)
< 0.0001 C versus CKD n.s. C versus HD**** CKD versus. HD***
C-reactive protein (mg/L)
6.1 ± 3.0 5.6 (3.8–7.1)
7.5 ± 8.2 5.0 (2.4–7.2)
6.9 ± 6.9 5.5 (2.0–9.0)
n.s.
Proteinuria (g/L)
Not assessed (dipstick negative)
0.22 (0.09–1.10)
Not assessed
Not evaluated
Results are expressed as mean ± standard deviation and in case of high interindividual variability also as medians (interquartile ranges). Comparison: one-way ANOVA and Tukey’s multiple comparison test. **** < 0.0001, *** < 0.001, ** < 0.01.
