Chronotropic Modulation of the Source-Sink Relationship of Sinoatrial-Atrial Impulse Conduction and Its Significance to Initiation of AF: A One-Dimensional Model Study

Figure 7

Coupling-induced changes in SAN ion currents. (a, top left panel) Time-course of SAN (red) and atrial (black) , before (solid line) and after (dotted line) electrical coupling with (, ) values chosen as reported in Results. The simulation corresponds to NT conditions. (a, remaining panels) SAN ion currents before (solid) and after (dotted) coupling. (b) Coupling-induced percent changes of the SAN peak ion currents under the 7 simulated treatments. Percent coupling-induced changes of the beating CL are reported in the inset.

(a)

(b)