miR-126 Is Involved in Vascular Remodeling under Laminar Shear Stress

Figure 5

miR-126, miR-126, and SDC-4 expression in control and atherosclerotic mice. Twenty-week-old mice aortas were isolated from wild-type (WT) and Apo-E KO mice for miRNA and mRNA studies at the indicated times. CKD mice were subjected to 10 weeks of uremia. (a) miR-126 expression expressed as RQ normalized to U6. (b) SDC-4 expression normalized to GAPDH. Values are expressed as mean ± SD of 3 independent experiments (AU: arbitrary units). Student’s -test, for miR-126: (WT sham versus Apo-E CKD); for SDC-4: (WT sham versus WT CKD), (WT sham versus Apo-E CKD).

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