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BioMed Research International
Volume 2015 (2015), Article ID 502846, 5 pages
Research Article

First Report of Hepatitis E Virus Infection in Sika Deer in China

1College of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin 130118, China
2State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China
3Jilin Entry-Exit Inspection and Quarantine Bureau, Changchun, Jilin 130000, China
4Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Disease, Yangzhou, Jiangsu 225009, China

Received 20 January 2015; Revised 25 March 2015; Accepted 25 March 2015

Academic Editor: Mohamed T. Shata

Copyright © 2015 Xiao-Xuan Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hepatitis E virus (HEV), a single stranded RNA, nonenveloped virus, belongs to the genus Hepevirus, in the family of Hepeviridae. In this study, 46 (5.43%) out of the 847 serum samples from sika deer (Cervus nippon) were detected as seropositive with hepatitis E virus (HEV) by enzyme linked immunosorbent assay (ELISA). These samples were collected from Inner Mongolia and Jilin and Heilongjiang provinces in China, between October 2012 and October 2013. Seroprevalence of HEV infection in male and female deer was 4.82% and 6.52%, respectively. HEV seroprevalence in sika deer from different geographical locations varied from 3.13% to 6.73%. There was no significant difference in HEV seroprevalence between sika deer collected in autumn (5.65%) and winter (4.85%). This is the first report of HEV seroprevalence in sika deer in China, which will provide foundation information for estimating the effectiveness of future measures to control HEV infection in sika deer in China and assessing the potential risk of humans infected with HEV after consumption of undercooked or raw meat from infected sika deer.