Research Article
Mathematical Model of Innate and Adaptive Immunity of Sepsis: A Modeling and Simulation Study of Infectious Disease
Table 4
Definition of parameters and experimental values in monocyte immune response model.
| Parameters | Description | Value | References |
| | Influx rate of monocytes into blood vessel | 0.5/h | [44] | | Rate at which pathogens are killed by inflammatory monocytes | 7/per monocyte/h | [47] | | Influx rate of monocytes in liver | 80/h | [48] | | Resting monocyte carrying capacity in blood vessel | 50000 cells | [49] | | Apoptotic rate of resting monocytes per hour | 0.2/h | Estimated | | Apoptotic rate of activated monocytes (monocytes-derived-macrophage) per hour | 0.08/h | [50] | | The maximum number of HMGB-1 being released by monocytes per enzyme molecule per hour | 0.001/h | Estimated | | Number of monocytes at which the reaction rate is half of maximum production rate | 10000 cells | Estimated | | Concentration of monocytes which phagocytose half of Salmonella | | [47] | | Unbinding rate of binding activated monocytes | 0.4/h | [51] | | Degradation rate of HMGB-1 | 0.5–3/h | Estimated | | Rate at which activated neutrophils are killed by inflammatory monocytes | 200/monocyte/h | Estimated |
|
|