Anti-Lung Cancer Activity of the Curcumin Analog JZ534 In Vitro

Figure 2

JZ534 inhibited lung cancer cell proliferation. (a) H460, A549, H1975, HCC827, and HL7702 were incubated with JZ534 (0.5, 1, 2, 4, and 8 μM) or curcumin (0.096, 0.48, 2.4, 12, and 60 μM) for 72 h; OD values were tested by MTT, and then the inhibition rate and IC₅₀ were calculated. The assay was performed in triplicate. Data are presented as the means ± SD. (b) The number of colonies was counted after A549 and H460 cells were incubated with 4 μM JZ534 or curcumin for a week and stained with crystal violet.

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