Molecular Imaging-Guided Interventional Hyperthermia in Treatment of Breast Cancer

Figure 3

Representative plan for GK surgery treating locally recurred brain metastases with guidance by ¹¹C methionine- (MET-) PET/MRI fusion imaging. The patient was a 42-year-old woman with brain metastases from breast cancer who had received 4 previous treatments with GK. (a) A big discrepancy was clearly seen between the area with good contrast enhancement on the T1-weighted MR image (indicated by arrowheads) and (b) the area with elevated MET uptake (indicated by arrows). (c) The PET-MRI fusion image was rendered after constructing a binary image (shown in white), indicating areas with MET uptake 1.4 times higher than that in the contralateral brain. (d) The GK strategy was to administer a higher radiation dose to areas with higher MET uptake. ¹¹C methionine uptake was markedly reduced in a MET-PET image obtained 6 months after the GK (i.e., good control of active cancer). Reprinted, with permission, from [40].

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